Papers by Keyword: Autograft

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Authors: Yao Hua Zhao, Hui Guang Yang, Hai Tao Deng, Li Hong Xu, Da Zhong Zou, Yao Ming Shen, Wei Qi Huang, Dong Liang Yuan
Abstract: Objective: To explore the feasibility and clinical value to keep the denatured dermis in the deep II degree burns. Methods: With the consent of the 41 patients, their burn wounds were divided into two groups, one group is called the observation group, and the other is called the control group. Comparison was made in the same body. Apply retaining denatured dermis plus autograft skin in the observation group and scab removing plus autograft skin in the control group, individually. Then compare the following factors of the two groups: blood loss amount, 14th day wound healing rate, and the color B-measurement of the thickness from the skin surface to fascia thickness. Results: The blood loss was 10.2 ± 2.3 ml in the observation group, 39.2 ± 6.1 ml in the control group. t = - 22.3, P = 0.000; 14d wound healing rate was 75.6% (31/41) in the observation group, and 87.8% (36/41) in the control group. 2= 0.581; P > 0.05. The thickness of skin and subcutaneous tissue was measured to be 1.2 ± 0.5cm in the observation group, and 0.8 ± 0.3cm in the control group, t = 19.4, P = 0.000. Conclusions Retain denatured dermis and implant autograft skin surgery can reduce the intensity of operation, it can also benefit the skin and soft tissue reconstruction. Thus, it is one of the most effective surgical methods in the treatment of deep II degree burns.
Authors: Ian Thompson, Larry L. Hench
Abstract: Autogenous bone grafts are considered to be the gold standard in maxillo-facial surgery. However, drawbacks of donor site morbidity and unpredictable rates of resorbtion often limit their use. In vivo tests have shown that 45S5 bioactive glass particles placed in critical size bone defects lead to regeneration of new bone that has the structural characteristics and architecture of mature trabecular bone. In vitro tests using primary osteoblast cultures have shown that the bioactive glass particles release ionic dissolution products that provide genetic stimuli that control osteoblast cell cycles and lead to rapid growth of mineralized bone nodules. These in vitro and in vivo results led to approval of use of bioactive glass particles and monolithic bioactive glass implants for use in maxillo-facial reconstructions after removal of bone cysts and trauma, as described by several case histories.
Authors: Simon Storgord Jensen, Michael M. Bornstein, Michel Dard, Dieter Bosshardt, Daniel Buser
Authors: Monica Calasans-Maia, G.V.O. Fernandes, Antonella M. Rossi, Eliane Pedra Dias, G.D.S. Almeida, F.F. Mitri, José Mauro Granjeiro
Abstract: Hydroxyapatite (HA), widely used as bone graft, can be modified by the incorporation of bivalent cations (Mg2+ and Zn2+) and its gradual release could favor the bone repair. The purpose of this research was to evaluate the effect of the HA and zinc-containing hydroxyapatite (Zn-HA) in the bone repair in rat calvaria in comparison to autogenous bone. Critical size defect in the calvaria was filled with the graft material and the samples were harvested at the 30, 90 and 180 days. The light microcopy observations showed the biocompatibility of the graft materials. In the Zn-HA group the area of neoformed bone was larger than in the HA group, but smaller than in the autograft. A fibrous connective tissue was more evident around HA granules. It could be conclude that the presence of zinc ions in HA crystal accelerated the osteogenesis and increased the area of newly formed bone in relation to HA.
Authors: G.V.O. Fernandes, Monica Calasans-Maia, F.F. Mitri, Vagner Gonçalves Bernardo, Antonella M. Rossi, G.D.S. Almeida, José Mauro Granjeiro
Abstract: Biomaterials for treatment of bone defects have been studied for a long time. Alloplastic materials, mainly hydroxyapatite (HA), are under intense investigation due to its biocompatibility and osteoconductive properties. The HA can be modified by the incorporation of bivalent cations as Zn2+ known as a positive effectors for bone repair. The purpose of this study was to evaluate comparatively the effectiveness of 5% zinc-containing hydroxyapatite (ZnHA) in the treatment of critical size defect (CSD) in rat’s calvaria. CSD (8mm diameter) created in the skull of forty-five Wistar rats were filled with autogenous bone, HA and ZnHA. Skulls harvested after 30, 90 and 180 days were submitted to histological processing for paraffin embedding. Sections of 5 µm-thick stained with hematoxylin and eosin (HE) allowed histomorphometric analysis. The area of neoformed bone increased (p<0.001) from 30 to 180 days irrespective to treatment groups. ZnHA and the control group showed a large at 180 days but no significant difference compared to HA. Therefore, we concluded that both biomaterials are biocompatibles and osteoconductors, promoting new bone formation and apposition of bone on the surface throughout the periods and the addition of zinc improved the osteogenesis.
Authors: Tae Gyun Kim, Ui Won Jung, C.S. Kim, Yong Keun Lee, Seong Ho Choi, Kyoo Sung Cho, Chong Kwan Kim, Jung Kiu Chai
Abstract: This study evaluated periodontal repair and biomaterial reaction following implantation of a calcium carbonate and autogenous bone on the regeneration of 3-wall intrabony defects in the beagle dogs. The surgical control group received a flap operation only, while the experimental group I was treated with a calcium carbonate and the experimental group II was treated with autograft. The subjects were sacrificed 8 weeks after surgery and a comparative histometric analysis was done. No root resorption or ankylosis were observed in the experimental group. ANOVA post Hoc test showed that the experimental group II produced statistically significant higher gain in connective tissue adhesion, new cementum regeneration and new bone formation. These results suggest that the use of autograft in 3-wall intrabony defects has a significant effect on new cementum and new bone formation height.
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