Papers by Keyword: Bioactive

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Authors: Larry L. Hench
Authors: Ian R. Dunkley, Scott M. Vickers, Jeffrey Badura, Jeffrey Toth
Abstract: The healing mechanism of osteoconductive biphasic calcium phosphate granules was investigated by a histological assessment of early-stage bone deposition and remodeling. The deposition of de novo bone on the scaffold granules was observed to initiate at the defect periphery by week one and in the bulk of the defect incorporating the granules by week four. New bone tissue was deposited in the space provided by the macroporosity and was observed in direct apposition to the implanted material confirming the bioactivity of the biphasic calcium phosphate. The granules were removed through a cell-mediated resorption process that was observed to begin as early as week two following surgery. Mature lamellar bone, fatty bone marrow, and vascularization was observed throughout the bulk of the defect with the cortical shell healed by week twelve. This healing mechanism was found to balance bone formation and implant resorption resulting in complete healing of the corticocancellous defect in the rabbit femoral condyle.
Authors: P. Sooksaen, K. Chaithep, T. Saliwong, T. Duangart
Abstract: Apatite-wollastonite bioactive glass-ceramic scaffolds were fabricated from the SiO2-CaO-P2O5 MgO-CaF2 glass system by controlled crystallization between 800 and 1200C of the melted and quenched glass powder. Wood powder with controlled particle size distribution was used to obtain bioactive glass-ceramic scaffolds by burning-out process during crystallization of glass. Bioactive phases of apatite and wollastonite were found in all crystallized samples but the relative amount depended on the crystallization temperature. The bioactivity was studied via simulated body fluid (SBF) solution from 2 to 12 weeks. After soaking for 2 weeks, a porous hydroxyl-carbonate apatite (HCA) layer formed at the SBF-glass ceramic interface and the HCA layer thickness increased at longer soaking periods. This study led to a promising platform for hard tissue engineering.
Authors: Anna-Maija Haltia, Harri Heino, Minna Kellomäki
Authors: Tian Tian, Liu Hui, Gu Ming Jun, Jin Ying
Abstract: In this work, Ag-AgCl-TiO2 coating was fabricated on titanium substrates to obtain an implant material having excellent antibacterial property and bioactivity. The coating was investigated by scanning electron microscopy and X-ray diffraction. The bioactivity of coatings was examined by simulated body fluid soaking test. To verify the susceptibility of implant material surface to bacterial adhesion, S. aureus (Sau), E. coli (Eco), K. pneumoniae (Kpn), P. Aeruginosa (Pae), four types of major pathogen were chosen for in vitro antibacterial analyses. The results showed that Ag-AgCl-TiO2 coating had excellent antibacterial property and bioactivity.
Authors: Mu Qin Li, Li Jie Qu, Chen Ma, Shi Qin Yang
Abstract: This study examined the bioactive and stability of calcium phosphate- polypyrrole(ppy) composite coatings on titanium alloys by electrochemically deposition in simulated body fluid (SBF). Change of coatings mass and SBF pH during coatings soaked in SBF indicated that ppy reduces the decomposition of coatings. The surface morphology of coatings characterized by SEM showed that the stability of composition coating was superior to that of single coating. XRD indicated that ppy induces CO3 2- enter calcium phosphate coating, which showed that the composite coatings possess better bioactive. Thus, this electrochemical deposition provides an effective method of ppy incorporation at physiological temperature, which can offer excellent bioactive and stability of coatings, with a potential for sustained release of therapeutic agents as required for metallic implant fixation.
Authors: Koji Goto, Masami Hashimoto, Hiroaki Takadama, Jiro Tamura, Shunsuke Fujibayashi, Shin Hasegawa, Keiichi Kawanabe, Tadashi Kokubo, Takashi Nakamura
Abstract: Three types of polymethylmethacrylate (PMMA)-based composite cements containing 40− 56 wt% micron-sized titania (titanium oxide) particles, designated ST2-40c, ST2-50c, and ST2-56c, were developed as bone substitutes for vertebroplasty, and evaluated for their mechanical, setting, and biological properties. In animal experiments, ST2-50c and ST2-56c were implanted into rat tibiae and solidified in situ. Their biological properties were evaluated at 6 and 12 weeks after implantation. Compressive strength, bending strength, and bending modulus increased with increasing titania content. Peak temperature during the setting reaction decreased as the filler content increased. ST2-56c had direct contact with bone over larger areas than ST2-50c at 6 and 12 weeks. Data from the present study indicated that ST2-56c is a good candidate as a bone substitute for vertebroplasty.
Authors: C. Marques, Luis Henrique Leme Louro, Marcelo Henrique Prado da Silva
Abstract: Bioactive ceramics have the ability to chemically bond to bone. This class of biomaterials can be used as coatings on metallic implants, alloplastic bone defect fillers and as scaffold for tissue engineering. The most widely used bioactive ceramics are hydroxyapatite, Ca10(PO4)6(OH)2 and tricalcium phosphate, Ca3(PO4)2. This study presents new bioactive ceramics based on Nb2O5 and Ta2O5. These materials were produced from bioinert ceramics chemically activated by an alkali hydrothermal treatment. Scanning electron microscopy, energy dispersion X-ray spectroscopy and X-ray diffraction analyses on samples incubated in simulated body fluid showed the presence of bone-like apatite, confirming that the modified ceramics surface became bioactive.
Authors: Livia Bandici, Simona Ioana Vicas, Gheorghe Emil Bandici, Alin Cristian Teusdea, Simona Cavalu
Abstract: In this paper, grapes were processed by using high frequency electromagnetic field in order to obtain a high quality wine in terms of bioactive compounds content with antioxidant activity. The experimental setup comprise an applicator with adjustable power between 100-1000 W, software assisted, in order to process three varieties of grapes (Muscat Ottonel, Merlot, Pinot Noir), that were harvested in 2014 in the Crişana-Sântimreu vineyard. The total polyphenol compounds were measured using the Folin-Ciocalteu spectrophotometric method, and the antioxidant capacity was determined by the FRAP method. The results have shown that the use of high frequency electromagnetic field in grape processing leads to the diffusion of the bioactive compounds with antioxidant activity in the final product. In the same time, it is also an effective method in terms of energy consumption.
Authors: Larry L. Hench
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