Papers by Keyword: Bioactivity

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Authors: Inga Narkevica, Aigars Reinis, Lauma Bugovecka, Ingus Skadins, Errj Sansonetti, Juta Kroica, Jurijs Ozolins
Abstract: Biomaterials used in bone repair must satisfy certain criteria in order to perform without undesirable immunological response. They must be biocompatible and should inhibit bacteria adhesion on the surface, that could led to strong inflammatory process and implant failure. Our study reveals a synergistic effect on bioactivity and bacteriostasis effect of the TiO2 ceramics with different surface properties and provides insight into the design of better biomedical implant surfaces. The results show that UV light irradiation has great impact on hidrophilicity of TiO2 ceramics, but little effect on the sample bacteriostatic effect and bioactivity. TiO2 ceramic samples showed no or very low bacterial adhesion. Nevertheless, in vitro bioactivity showed TiO2 ceramic that was thermally treated at lower temperature. Thus for bone repair it’s suggested to use TiO2 ceramic sintered at lower temperature in order to provide bioactivity with bacterostatic effect and use UV-light irradiation to improve hidrophilicity.
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Authors: Ehsan Sharifi Sede, Shamsedin Mirdamadi, Hossein Arabi
Abstract: This study sought to create a biocomposite of Magnesium and Titanium via a powder metallurgy technique. Powder metallurgy technique was used to produce three different volume percentages of Magnesium (30% , 35% , 40%). Titanium powder was mixed with Magnesium, then the samples were compressed by 1800 Bar using a cold, isostatic press process. The samples were then sintered to 850 for 100 min. At this temperature, the compressive yield strength was increased to 210 Mpa and significantly depended on the volume percent of Magnesium present, the core size and temperature of sintering. The bioactivity of the samples in a simulated body fluid (SBF) was also investigated. When the samples were immersed in the simulated body fluid for a 14 and 28 days, calcium and other elements were found to be deposited on the surface. Additionally, it was found that TiO2 has the ability to induce the formation of bone-like apatite in the SBF. In addition, the degradation product of Magnesium in a biological system caused a rise in the pH and environment for the deposition of calcium and other element on the surface were enhanced. Finally, the samples were analyzed using XRD, EDS, and optical and scanning electron microscopy (SEM).
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Authors: Yan Bao Li, Qing Lin, Jun Sheng Chen, Xiang Hui Lan, Chun Hua Lu, Dong Xu Li, Zhong Zi Xu
Abstract: The bioactivity of potassium titanate whiskers (PTW) was evaluated by soaking in simulated body fluids (SBF, Kokubo solution). At first, PTW was chemically treated by 1 M HCl and 1 M NaOH solutions at 60 oC for 48 h, respectively. Then PTW before and after treated were soaked in SBF solution and cultured at 37 oC for different times. The apatite deposit on PTW was examined by FTIR and SEM/EDX. The results showed that there was not apatite deposit on the raw PTW even after soaked for 14 days while apatite appeared on the treated PTW after soaked for only 7 days. This implies that treatment by HCl/NaOH solutions can improve the in vitro bioactivity of PTW. The possible mechanism is that more Ti–OH groups occur after treatment and induce Ca2+ and PO4 3- aggregate and accelerate to deposit of apatite. The bioactive PTW with good biocompatibility is a potential candidate as reinforcing agent to improve the mechanical properties of calcium phosphate ceramics or cements.
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Authors: Yi Kai Chen, Xue Bin Zheng, Ba Oe Li, You Tao Xie, Chuan Xian Ding
Abstract: Biomaterials with good biocompatibility and anti-bacterial property were becoming attractive to researchers, so we used the chemical method to produce anti-bacterial vacuum plasma sprayed titanium coatings and studied In vitro bioactivity, cytotoxicity and blood compatibility of the anti-bacterial coatings in this paper. In order to evaluate the bioactivity of the treated titanium coatings, the coatings were immersed in simulated body fluid (SBF). The treated titanium coatings showed good bioactivity in this experiment. Two different methods were used to assess the cytocompatibility of the treated titanium coatings. One was extract test; the other was direct contact test. The results indicated that cells spread and adhered well on the coatings. The blood compatibility of the coatings was evaluated by haemolysis ratios. The hemolysis ratios of the coatings were below 2%, indicating of nonhemolysis for the coatings.
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Authors: Yang Leng, Ren Long Xin, Ji Yong Chen
Abstract: Bioactive calcium phosphate (Ca-P) formation in bioceramics surfaces in simulated body fluid (SBF) and in rabbit muscle sites was investigated. The examined bioceamics included most commonly used bioglass®, A-W glass-ceramics and calcium phosphates in orthopedic and dental applications. The Ca-P cyrstal structures were examined with single crystal diffraction patterns in transmission electron microscopy, which reduced possibility of misidentifying Ca-P phases. The experimental results show that capability of Ca-P formation considerably varied among bioceramics, particularly in vivo. Octacalcium phosphate (OCP) was revealed on the all types of bioceramics in vitro and in vivo experiments. This work leads us to rethink how to evaluate bioactivity of bioceramics and other orthopedic materials which exhibit capability of osteoconduction by forming direct bonding with bone.
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Authors: Mariny Fabiéle Cabral Coelho, Maria E.R. Cronemberger, Juliete N. Pereira, Sandra Nakamatsu, Sylma Carvalho Maestrelli, Eliana C. da S. Rigo, Neide A. Mariano
Abstract: Titanium and stainless steel are examples of biomaterials widely used in dental and orthopedic implants owing to their properties of good corrosion resistance and excellent biocompatibility. This paper reports on a study of the biomimetic method applied to titanium (cp-Ti) and 316L stainless steel. The method consists in immersing the metal substrate in a synthetic solution of SBF (simulated body fluid) whose composition, pH and temperature resemble those of human blood plasma. The coating on the two metals was effective for obtaining hydroxyapatite, which was confirmed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR).
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Authors: Chuan Zhong Chen, Xiang Guo Meng, Hui Jun Yu, Han Yang, Ting He, Dian Gang Wang, Shi Gui Zhao
Abstract: Bioactive glass, because of the good bioactivity and biocompatibility, is considered to be the most ideal material for bone repair and replacement. However, the mechanical properties of the bioactive glass are great different from that of human bone. Coating bioactive glass on the surface of Ti or Ti-alloys that possess excellent mechanical properties can offset the disadvantage. In this paper, the research progress in the coating preparing techniques such as enameling, sol-gel, electrophoretic deposition, plasma spraying and pulsed laser deposition is summarized, the advantages and existent problems of the coating preparation techniques are discussed, and the development foreground is forecast.
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Authors: Noorazimah Ab Llah, Shamsul Baharin Jamaludin, Zuraidawani Che Daud
Abstract: Research and development on the biomaterials are increasing due to the demand for materials that can bond to the living bones and by any chance can avoid second surgery procedure. Good bonding between bones and biomaterials or artificial implant can avoid loosening that due to the friction and wear. Currently, magnesium alloys are being actively researched because of their ability to serve as structural support in short term and can be absorbed in the body after healing process is completed. The addition of bioactive components such as hydroxyapatite and bioglass into magnesium is made to improve the bioactivity behavior of magnesium alloys. This paper summarizes the past and current studies of magnesium alloys in regards of in vitro bioactivity behavior, biomineralization and apatite formation mechanism.
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Authors: Bang Cheng Yang, Qi Feng Yu, Ji Yong Chen, Xing Dong Zhang
Abstract: The bioactivity of a composite of titania and hydroxyapatite was studied in vitro in this paper. After the titania ceramics was added 10% HA, it could induce apatite formation in simulated body fluid in 2d, while the pure titania ceramics could not induced apatite formation even after 14d. After the composite of titania and HA was subjected to alkali-heat treatment, it has a faster speed for apatite formation in SBF than the composite without treatment. When the osteoblast was cultured on the materials, the amount of osteoblasts attaching on the composite was more than that on the pure titania ceramics. It has the most osteoblasts cells on the composite subjected to alkali-heat treatment. These results showed that the composite of titania and HA is a bioactive materials, while the alkali-heat treatment could improved the bioactivity of this composite.
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