Papers by Keyword: Bioadhesive

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Authors: C.Q. Fang, R. Auras, S.E. Selke
Abstract: Distiller's Dried Grains with Solubles (DDGS) is used to replace starch as a major feedstock material to produce bio-adhesive. The experimental conditions and the preparation process of the DDGS bioadhesive are outlined. The production and performance of DDGS adhesives were directly influenced by the heating temperature, heating time and concentration of hydroxide (NaOH) solution. When the heating temperature was 90 °C, the heating time was 10 min, and the concentration of NaOH solution was 30g/L, the yield of the DDGS adhesive was 61.6% wt/dry wt. The DDGS adhesive was less sensitivity to humidity than commercial starch adhesive.
Authors: Rungsarit Koonawoot, Sittiporn Punyanitya, Chatchai Tirapong, Kritsada Boonchom, Anirut Raksujarit
Abstract: Successful human tissue adhesives depend on sure parameters which cannot be matched by any one adhesive. In this work, the novel human tissue adhesive is fabricated from gelatin and coconut shell carbon nanopowder composite. Characteristics of the carbon powder and the product samples were then investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM). Mechanical characterization and tissue adhesive bonding test of the final product were also performed.
Authors: Yasuhiro Yoshida, Takumi Okihara, Mariko Nakamura, Takuya Matsumoto
Abstract: A biodegradable material that bonds to hard tissues such as bones and teeth is urgently needed for medical and dental applications. However, such materials are not available in today’s clinical practice of orthopedics and dentistry. Therefore, we synthesized biodegradable phosphorylated pullulan to develop a biomaterial that combines primary properties such as high biocompatibility, good bonding potential to hard tissue, high strength, biodegradability, and osteoconductivity. The pharmacopoeial polysaccharide pullulan was chemically functionalized with dihydrogen phosphate groups. Phosphorylated pullulan was formed network by adding calcium ion, making the composite less soluble in water. Adhesive force measurement revealed that adhesiveness of the pastes before setting can be controlled through optimization of additives. In addition, histological evaluation revealed that phosphorylated pullulan-based composite possesses high biocompatibility. These results indicate that phosphorylated pullulan can be used as a key material for regeneration and reconstruction of bone and tooth.
Authors: Watee Puntuwat, Sathiya Wongsa, Jiraporn Poonyawatpornkul, Sittiporn Punyanitya, Anirut Raksujarit
Abstract: The objective of this work is make tissue adhesives agent from Thai rice starch, then test the final products for scientific and medical properties following the laws of Thai health ministry, to demonstrate that this product can be used safely, as same as the standard product. The principal raw material is pharmaceutical grade, Thai rice starch powder. The additives are hydroxyapatite (HA) nanopowder, carboxymethylcellulose, lactic acid, gelatin, polyvinylalcohol and glycerol. All materials will be mixed in distilled water under high temperature, and dried into starch tissue adhesives plate hydrogel. The final product will be kept in medical package and sent for sterilization by gamma radiation. These products will be characterized by scanning electron microscopy (SEM), x-ray diffraction (XRD), stability in water, and adhesive bond strength test in wet environment.
Authors: Naoki Nakajima, Hajime Sugai, Sadami Tsutsumi, Suong Hyu Hyon
Abstract: To improve the conventional and commercially-available medical adhesives such as cyanoacrylate, aldehyde-based, and fibrin glue, new bioadhesive has been prepared using medical and food additives as starting materials. Aldehyde groups could be easily introduced in dextran in the presence of sodium periodate in aqueous media, and the extent of the introduction could also be controlled. In vitro degradation speed of the hydrogel prepared by mixing of aldehyded dextran with ε-poly(L-lysine) at 37oC significantly varied by acetic anhydride concentration added to ε-poly(L-lysine) from < 5h to > 5 weeks. Bonding strength of the glue was 4 times higher than that of commercial fibrin glue and almost no cytotoxicity was observed, suggesting the development of novel self-degradable bioadhesive.
Authors: H. Marcal, T. Ahmed, N. Wanandy, J. Foster
Abstract: Extracellular matrices (ECM) derived from urinary bladder membrane (UBM) have demonstrated substantial potential for applications in tissue repair and reconstruction. However, these materials are limited by the requirement of suturing following surgery. In this paper, the coalescence of UBM with an advanced surgical adhesive demonstrated a suitable alternative to sutures for wound closure, prevention of fluid leakage and improvement of cell growth. This novel bioadhesive contains favourable characteristics that are suitable for tissue repair, support of cell growth, and influence cellular microenvironments that are biocompatible with peripheral nerve regeneration in the spinal cord.
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