Papers by Keyword: Blood Compatibility

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Authors: Yi Kai Chen, Xue Bin Zheng, Ba Oe Li, You Tao Xie, Chuan Xian Ding
Abstract: Biomaterials with good biocompatibility and anti-bacterial property were becoming attractive to researchers, so we used the chemical method to produce anti-bacterial vacuum plasma sprayed titanium coatings and studied In vitro bioactivity, cytotoxicity and blood compatibility of the anti-bacterial coatings in this paper. In order to evaluate the bioactivity of the treated titanium coatings, the coatings were immersed in simulated body fluid (SBF). The treated titanium coatings showed good bioactivity in this experiment. Two different methods were used to assess the cytocompatibility of the treated titanium coatings. One was extract test; the other was direct contact test. The results indicated that cells spread and adhered well on the coatings. The blood compatibility of the coatings was evaluated by haemolysis ratios. The hemolysis ratios of the coatings were below 2%, indicating of nonhemolysis for the coatings.
Authors: B.G. Li, Yun Qing Kang, Guang Fu Yin, Chang Qiong Zheng
Abstract: In this paper, the adsorption of human serum albumin (HSA), human serum fibrinogen (HFG) and human serum immune globulin (IG) on surfaces of diamond like carbon film (DLC), diamond film (DF) and graphite has been studied. The adsorption isotherms of single component protein solution and the competitive adsorption of binary system have been investigated by radioisotope 125 I labeling method. Results showed that (1) the adsorptive amounts of HSA on DLC is more than that of HFG, but the adsorptive amounts of HFG on DF and graphite are apparently more than those HSA; (2) the relative competitive adsorption ability of three proteins on DF and graphite surfaces is HFG > IG > HSA, but that on DLC is HFG ≈ HAS > IG, comparison with HSA, there is no apparent competitive adsorption superiority on DLC for HFG. These results indicated that there is no apparent distinction for the adsorption of three human serum proteins on DLC, but the adsorption of HFG on DF and graphite takes precedence in varying degrees. It probably makes rational explanation for the result of blood-compatibility tests in vitro that DLC is good, but DF and graphite are worse.
Authors: Jian Liu, Yang Yang, Fen Ju Liu, Qing Fang Liu
Abstract: To evaluate the blood and tissue compatibility of the dental implant samples, the whole blood clotting time, prothrombin time and partial prothrombin time, hemolytic rate and local implantation tests of the dental implant samples were determined, which will provide the basis for the clinical safety of such medical products. The WBCT, PT and PTT results showed that there were no significant difference (p> 0.05)between the testing groups and the negative control group, hemolysis rate of the dental implant samples was 1.38%, less than 5%, which in line with medical equipment blood compatibility test, all of these results indicated that the dental implant had a good blood and tissue compatibility.
Authors: Guo Jiang Wan, Nan Huang, An Sha Zhao, Ping Yang, Paul K. Chu
Abstract: Ammonia implanted silicon was performed by using plasma immersion ion implantation (PIII) to form a silicon nitride films. Blood compatibility of the prepared samples was investigated by platelets adhesion testing. It showed less activation i.e. lower thrombosis risks occurs on the prepared silicon nitride films than control silicon sample. The enhanced blood compatibility of the material is attributed to the modified surface properties such as hydrophilicity from thermodynamic adsorption perspective, which is related to surface chemical bonding states achieved by PIII process.
Authors: Feng Juan Jing, Lu Wang, Y.W. Liu, J.Y. Cheng, Yong Xiang Leng, R.K.Y. Fu, X.B. Zhao, Paul K. Chu, Nan Huang
Abstract: Cerium oxide films have been fabricated using dual plasma deposition. X-ray diffraction. (XRD) reveals a crystalline phase and X-ray photoelectron spectroscopy (XPS) shows that La exists predominantly in the +4 oxidation state. The activated partial thromboplastin time is longer than that of blood plasma and stainless steel. Furthermore, the numbers of adhered, aggregated and morphologically changed platelets are reduced compared to low-temperature isotropic carbon (LTIC). HUVEC cells exhibit good adhesion and proliferation behavior on cerium oxide films. This study suggests rare earth oxide films are potential blood-contacting biomedical materials.
Authors: S. Takashima, S. Takemoto, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka
Authors: S. Takemoto, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, S. Takashima
Authors: Jin Wang, P. Li, H. Sun, Ping Yang, Y.X. Leng, Ji Yong Chen, Nan Huang
Abstract: We report a study involving chitosan chains immobilized on poly (ethylene terephthalate) (PET) films by plasma and ultraviolet (UV) grafting modification. The surface structure of the modified PET is determined by means of attenuated total reflection Fourier transform infraed spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The results show that the chains of chitosan are successfully grafted on the surface of PET. Platelet adhesion evaluation in vitro is conducted to examine the blood compatibility in vitro. Scanning electron microscopy (SEM) and optical microscopy reveal that the amounts of adhered, aggregated and morphologically changed platelets are reduced on the chitosan-immobilized PET films. The number of platelet adhered on the modified film is reduced by almost 48% compared to the amount of platelets on the untreated film. Our result thus shows that chitosan immobilized on the PET surface improves blood compatibility.
Authors: Jae Hoon Kim, Jun Sik Son, Kwi Deok Park, Jong Man Kim, Jae Jin Kim, Kwang Duk Ahn, Dong Keun Han
Abstract: In this study, newly synthesized zwitterionic PEG was grafted on Nitinol alloy using oxidation treatment. The surface property and blood compatibility of surface-modified Nitinols were examined. The results of surface analysis showed that the contact angle and the ratio of oxygen to carbon significantly decreased with Nitinol alloys. The total amount of fibrinogen (0.095 μg/cm2) adsorbed onto TiNi-PEG2K-N+-S- was lower than that of TiNi control (0.12 μg/cm2). The platelet adhesion decreased in the order of TiNi control > TiNi-MPEG2K > TiNi-PEG2K-N+-S. Particularly, zwitterionic PEG with PEG2K was proven better than any others. The results indicated that zwitterionic PEG surface could significantly suppress platelet adhesion and protein adsorption as compared to other samples. The present study suggested that grafted zwitterionic PEG structure may possess improved blood compatibility.
Authors: Akiyoshi Osaka, Tomohiko Yoshioka, Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa
Abstract: Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L)substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and prothrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.
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