Papers by Keyword: Blood Compatibility

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Authors: Feng Guo, Yang Yang, Fen Ju Liu, Qing Fang Liu
Abstract: Objective:To evaluate the blood compatibility of a central venous catheter in order to provide evidence for the safety of medical devices. Methods:The indexes of coagulation including thrombin time(TT), prothrombin time(PT), activated partial thromboplastin time (APTT) and fibrinogen (Fg) concentration, as well as the indexes of platelet function parameters including TXB2 and platelet count were measured, hemolysis test was conducted as well to detect the hemolysis rate of the sample. Results:There was no significant difference between the samples and negative controls on indexes of coagulation and platelet function (p>0.05), hemolysis test showed that the hemolysis rate of the sample was 1.35% (less than 5%), which was coincident with the criteria of the medical devices. Conclusion:The test sample of central venous catheter has good blood compatibility.
Authors: Ying Huang, Yang Yang, Fen Ju Liu, Qing Fang Liu
Abstract: The aim of this study is to evaluate the blood compatibility of disposable burette transfusion apparatus and provide the basis for the clinical safety of medical products. Whole blood clotting time (WBCT), prothrombin time(PT),partial prothrombin time(PTT), hemolytic rate and bacterial endotoxin were measured. The results showed that there was no significant difference between the samples and the negative control on indexes of WBCT, PT and PTT (p>0.05), hemolysis test showed that the hemolysis rate of the sample was 1.38% (less than 5%), which was coincident with the criteria of the medical devices. Endotoxin levels were lower than 0. 5 EU/ml. All of the results above suggested that the disposable burette transfusion apparatus had a good blood compatibility and no pyrogen.
Authors: Yan Fei Zhao, Xiu Fen Wang
Abstract: In this paper, water-soluble polymer PEG of different molecular weight was grafted on the SIS films by plasma surface grafting modification. These surface modifed SIS films were characterized by contact angle measurement, ATR-FTIR and XPS. The contact angle of water decreased significantly while the surface free energy and hydrophilicity increased. The relative ratio of oxygen to carbon increased from 0.06 to 0.21 . All the results revealed that the PEG molecules were incorporated onto the surface of the SIS films through covalent bonds and the surface properties changed to some extent. The blood compatibilities of the surface-modified SIS films were examined using APTT, APTT of the SIS-PEG2000 exhibted the best blood compatibility
Authors: Ping Lan, Wei Wang, Jian Da Cao
Abstract: Heparin-like anticoagulant materials have been intensively studied over the past several years, many of effective works focus on the preparation of homogeneous sulfonated polymer and further anticoagulation and filtration properties.1 Due to high water-soluble properties of homogeneous materials, its applied scope is limited. In this study, nanofibrous membrane of cellulose acetate is chosen. By controlling degree of hydrolysis on the membrane surface and its further surface sulfonation, heparin-like surface has been built on cellulose derivative membranes where there are plenty of sulfonic acid group. In this paper, some testing means such as surface contact angle, ATR-FTIR, XPS and platelet adhesion are used to characterize membrane properties. The results show that our research approach is feasible, effects of hydrolysis and sulfonation are obvious on cellulose acetate membranes. In the meantime, the surface hydrophilicity of membrane is increased significantly; In addition, patelet adhesion experiments show that platelets adsorption decrease obviously after heparin-like treatment on the cellulose acetate membrane, showing an excellent anticoagulant activity.
Authors: F. Li, Jin Wang, H. Sun, Nan Huang
Abstract: Poly(ethylene terephthalate) films were exposed under argon plasma glow discharge and induced polymerization of acrylic acid (AA) in order to introduce carboxylic acid group onto PET (PET-AA) assisting by ultroviolet radiation. Hirudin-immobilized PETs were prepared by the grafting of PET-AA, followed by chemical reaction with hirudin. The surface structure of the treated PET is determined by X-ray photoelectron spectroscopy (XPS). The wettability and surface free energy, interface free energy of the films is investigated by contact angle measurement. Platelet adhesion evaluatiion is conducted to examine the blood compatibility in vitro. Scanning electron microscopy (SEM) and optical microscopy reveal that the amounts of adhered, aggregated and morphologically changed platelets are reduced on hirudin-immobilized PET films.
Authors: Nan Huang, Ping Yang, Yong Xiang Leng, Jin Wang, Jun Ying Chen, H. Sun, Guo Jiang Wan, An Sha Zhao, Pei Dao Ding
Abstract: In the present paper, the scientific basis, technique approaches, the present status and the development trends of surface modification for blood contacting materials are discussed briefly. The work in authors’ Lab. is also presented.
Authors: Atiye Sadat Abednejad, Ghasem Amoabediny, Azadeh Ghaee
Abstract: Blood oxygenators play key role in Extra Corporeal Membrane Oxygenator (ECMO) system using for patients with acute respiratory problems, immature fetal and also in open heart surgery. Interaction between blood and blood oxygenator polymeric membrane surface lead to fouling phenomena which have negative effect on performance of this important medical device. A modification comprising surface activation, PEG immersing and PEG graft polymerization carried out to provide acceptable blood oxygenator performance, blood compatibility and reduction in heparin consumption at the same time. Modified membranes characterized by FTIR, contact angle measurements and Atomic Force Microscopy (AFM) analyses. Blood compatibility of modified surface was also detected by SEM images. Results clearly indicate that modifying membranes by PEG is an effective way for anti-fouling properties. Water contact angel reduction from 110ْ to 72ْ shows hydrophilicity enhancement, roughness increasing from 15 to 20 and blood compatibility improvement was investigated by SEM and AFM analysis results respectively.
Authors: Run Ping Jia, An Xin Zong, Xin Yao He, Lu Wei
Abstract: In this paper, for the purpose of improving the hemocompatibility and surface tension of thermoplastic polyurethane (TPU) elastomers, poly butylene glycol ether hexafluoride fluoride ether glycol (PF) mixture with polytetramethylene ether glycol (PTMEG) was used as soft segments to synthesize a series of fluorinated thermoplastic polyurethane elastomers (FTPU) by two-step polymerization. The hemocompatibility in vitro was evaluated with platelet-rich plasma (PRP) contact tests. It was found that almost no platelet adhesion and activation was observed on the surface of FTPU elastomer when fluorine content was above 6wt% because of its low surface energy. The results indicated that fluorinated chain can be easily enriched on the surface of films because of higher C-F bond energy which due to greater micro-phase separation.
Authors: S. Takashima, Y. Kusudo, S. Takemoto, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka
Authors: Jing Hua Li, Chuan Bao Cao, Xilan Ma, Yin Tang, He Sun Zhu
Abstract: The citric acid (CA) was added to the silk fibroin and Polyvinyl Alcohol (PVA) copolymer system. The blending 4% PVA was for improving the mechanical properties of the silk fibroin films. Citric acid amount varies from 0.5% to 2% of weight. The antithrombogenecity was characterized by in vitro clot time of prothrombin time (PT), the Activated partial thromboplastin time (APTT) and thrombin time (TT). The mechanical properties of the blending films were measured and the tensile strength and breaking elongation of films reached to 25.3MPa and 102%. The anticoagulant property results indicated that APTT and TT prolonged significantly, but PT has no effective change. We discussed the relationship between the structure and properties and proposed an anticoagulant mechanism.
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