Papers by Keyword: Drug Delivery

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Authors: Juan Wang, Gui Jun Li, Rui Jiang, Zhu Ping Yin, Shen Zhou Lu
Abstract: A method was developed to prepare the Antheraea Pernyi silk fibroin (ASF) microspheres using lysozyme as a model drug to estimate the application of ASF in drug controlled release field. The structure of ASF microsphere carried drug was characterized by X-ray diffraction and FTIR. The morphology and the influence of the microspheres on the degradation of lysozyme were investigated using scanning electron microscope. The results show that encapsulation rate was increased and drug content was decreased with the addition of lysozyme increasing. In vitro release of lysozyme from the ASF particles we demonstrated that the release kinetics depends on the pH. The pH played important roles in controlling lysozyme release profiles. It also can be seen that the degradation speed of lysozyme ASF microspheres slightly larger than the pure ASF microspheres.
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Authors: Shen Zhou Lu, Juan Wang, Li Mao, Gui Jun Li, Jian Jin
Abstract: Silk nanoparticles were easily obtained from regenerated Antheraea Pernyi Silk Fibroin (ASF). The morphology and average size of the silk particles was sensitive to pH value of fibroin solution. The diameter of nanoparticles prepared was in the range of 30 nm to 1000 nm with a narrow size distribution. On this process, the molecular conformation of regenerated ASF changed from α-helix to β-sheet structure. The shape of prepared nanoparticles were regular spherical structure when the pH value was about 4.3 (pI) in ASF solution. Doxorubicin hydrochloride (DOX) was loaded in the ASF particles as drug release model and the drug-loading ratio was 3.4 %. The release rate of DOX from ASF nanoparticles was pH sensitive. After 23 days release, there was still 84% DOX in the ASF nanoparticles. The result suggested that the ASF nanoparticles might be suitable microcarriers for drug delivery.
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Authors: Q. Qiu, Paul Ducheyne, P.S. Ayyaswamy
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Authors: Peih Jeng Jiang, Sarika Patel, Uwe Gbureck, Liam M. Grover
Abstract: There is a current need for the localized delivery of antibiotics in order to treat implant based infections. In this study, the efficacy of hydroxyapatite (HA) gels, HA cements, and silica gels in the delivery of vancomycin have been investigated and compared. Vancomycin release was monitored at set time points using a UV/VIS spectrophotometer (288 nm). The activity of the vancomycin released from the cements and gels was assessed using an agar diffusion test with Staphylococcus aureus. Vancomycin was released rapidly from both HA matrices, and the silica gel in the first day of the experiment, but the release rate was slowed considerably after 3 days for the HA gels. Following ten days of aging, 70% of the vancomycin remained in the HA gel matrix and the quantity released from the gel was shown to retain its effectiveness against Staphylococcus aureus.
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Authors: Cao Ming, Xiao Wan Song, Yu Jiao Zhang, Chang Zhi Xu, Peng Chen, Ru Xia, Tian Long Hu, Jia Sheng Qian, Ke Liang Wu
Abstract: pH responsive polymeric nanoparticles have emerged as a promising technology platform for targeted and controlled drug delivery in recent years. In this paper, endosomal pH-activatable doxorubicin (DOX) and core-crosslinked polymeric nanoparticles (DCNPs) were prepared and investigated for potent growth inhibition of human cancer cells in vitro. In vitro drug release studies, DOX conjugated nanoparticles with hydrazone bond showed a pH sensitive release phenomenon, that is, the releasing is significantly faster at mildly acidic condition with pH of 5.5 than that at physiological condition. Confocal laser scanning microscope (CLSM) observations revealed that DOX conjugated nanoparticles delivered and released DOX into the cytosols as well as cell nuclei of Hela cells following 6 h incubation. MTT assays demonstrated that these pH-sensitive DOX nanoparticles exhibited high antitumor effect to HeLa cells. The conjugated DOX polymeric nanoparticles may be a promising candidate as a nanoscale and pH-sensitive drug delivery vehicle for cancer therapy.
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Authors: Jun Hui Ni, Bai Shao Zhan, Jun Li
Abstract: This paper presents an integrated magnetic PDMS micropump for implantable drug delivery application. The micropump mainly consists of two structural PDMS layers: a PDMS functional layer that incorporates microchannels, a pump chamber and two planar check valves into a single layer, allowing for simple design and easy system integration, and the other PDMS membrane layer covering the pump chamber and holding a thin electroplated permalloy piece on top for magnetic actuation. The micropump can be driven by the interaction between the ferromagnetic permalloy and an external electromagnet, providing a remote and wireless operation method. Test results demonstrate that this micropump is able to produce a maximal flow rate of 0.15 μL/min at the driving frequency of 2 Hz with a volume resolution of approximately 1 nL per stroke, promising its application in various implantable biomedical systems.
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Authors: Pragnesh N. Dave, Lakha V. Chopda
Abstract: In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application inbiotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural features like as their large surface areas, tunable pore sizes in nanometer and well-defined surface properties. MSN materials which are comprised of a honeycomb-like porous structure with hundreds of empty mesoporous channel that are able to encapsulate relatively large amounts of biomolecules. They are ideal candidate for constructing multifunctional materials that encapsulate a variety of functional nanostructured materials. Multifunctional MSN materials have become one of the most attractive areas in nanobiotechnology and nanomedicine for various disease diagnosis and therapy. Multifunctional MSN have been successfully developed as a multifunctional platform to deliver therapeutic and diagnostic agents. Multifunctional MSNs are a highly promising platform for intracellular controlled release of drugs. In this review we discuss the recent developments in design and fabrication of multifunctional mesoporous silica nanoparticles in as efficient drug delivery applications such as the site-specific delivery and intracellular controlled release of drugs.Abbreviations;APTES; 3-aminopropyl triethoxy sialne, ATP; Adenosine triphospahate, CD; cyclodextrinCPT; camptothecin, CS; Chitosan,CTAB; cyltrimethylammonium bromide,DNA; Deoxyribonucleic acid,DOX; doxorubicin,EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide,FD; fluorescein disodium,FSP;Fluroscent particle ,IBU;ibuprofen,MCM; mobil composition material, MPS; 3-trimethoxylsilyl propyl methacrylate, MS; mesoporous silica,MSN; mesoporous silica nanoparticle, MSNs; mesoporous silica nanoparticles,MSNP; mesoporous silica nanoparticle,NPS; nanoparticles;PFDTES;perfluorodecyltriethoxysilane, PAA; polyacrylic acid,PR;photo responsive,PMAA; polymethyl methacrylate,SBF; simulated body fluid,TEOS;tetraethyl orthosilicate,TUNA;Thio undecyl-tetraethyleneglycoestero-nitrobenzylethyldimethyl ammonium bromide.
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Authors: Habibollah Faraji, Reza Nedaeinia, Esmaeil Nourmohammadi, Bizan Malaekeh-Nikouei, Hamid Reza Sadeghnia, Seyyed Payman Ziapour, Hoda Khoshdel Sarkarizi, Reza Kazemi Oskuee
Abstract: Nanotechnology as a multidisciplinary and scientific innovation plays an important role in numerous biomedical applications, such as molecular imaging, biomarkers and biosensors and also drug delivery. A wide range of studies have been conducted on using of nanoparticles for early diagnosis and targeted drug therapy of various diseases. In fact, the small size, customized surface, upgraded solubility, or multi-functionality of nanoparticles enabled them to interact with complex cellular functions in new ways which opened many doors and created new biomedical applications. These studies demonstrated that nanotechnology vehicles can formulate biological products effectively, and this nano-formulated products with a potent ability against different diseases, were represented to have better biocompatibility, bioaccessibility and efficacy, under in vitro and in vivo conditions.
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Authors: Suchada Chongprakobkit, Wanpen Tachaboonyakiat
Abstract: The aim of this research was to control the delivery of naproxen from emulsion-based sodium phosphorylated chitosan (PCTS) nanoparticles (PCTS nanoemulsion) by thermal stimulus. The dynamic light scattering and optical microscope results demonstrated that the droplet size of emulsion-based nanoparticles was sensitive to temperature. The PCTS nanoemulsion exhibited the droplet size around 230 nm at 30°C. Emulsion droplets were increased in their size over critical temperature of around 60°C. Besides, the droplet size was reversible to 270 nm when the temperature decreased to 30°C. This indicated that the droplet size of PCTS nanoemulsion was sensitive to thermal stimulus. It might owe to molecular chain extension and rearrangement of PCTS at the interface of emulsion droplets. Therefore, the control release of naproxen from PCTS nanoemulsion via thermal stimulus was investigated. In vitro release study showed that the naproxen was released from PCTS nanoemulsion in high amount over critical temperature. These results indicated that the PCTS nanoemulsion exhibited a potential application as intelligent thermal sensitive drug carrier.
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Authors: Dong Xing Cao, Yi Tong Cao, Hui Li, Xiu Hong Wang, Li Zhu Lei
Abstract: In clinic practice, a strong appeal for painless transdermal injection is pursued, especially for patient drug delivery that cannot be administered orally. A new disposable painless syringe with MEMS technology is presented. The mode of micro needle array and a flexible PDMS container of hemisphere shape are given, and the behavior of the drug liquid flow through the needles is described based on port ontology to model miniature syringe and explains the phenomena of clog formation. The analysis and formulas have theoretically been derived, and the performances and the clog phenomena have been simulated. Therefore, micro needles inserted into the human skin can realize painless injection based on port ontology modeling.
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