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Evaluation of Osteoblast Responses to Silver-Hydroxyapatite/Titania Nanoparticles In Vitro

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Abstract:

In the present in vitro study, osteoblasts proliferation, vitality and ultrastructure were investigated when cultured in the presence of silver-hydroxyapatite/titania nanoparticles (nAg_HA/TiO2) compared to HA nanoparticles (nHA) at various concentrations and cell culture without nanoparticles for up to 120 hours. Results confirmed the detrimental influences of both nAg_HA/TiO2 and nHA on osteoblast growth.Cell vitality was slightly higher during the earlier 24h, but after that was inhibited. Both cell proliferation and vitality by addition of nanoparticles were restricted with concentrations of nanoparticles increasing. However, the respiration rates by addition of nanoparticles were showed higher than that of the cell culture without nanoparticles. No remarkable ultrastructure changes were showed in the osteoblasts exposed nanoparticles. The difference in cell proliferation, vitality and ultrastructure between nAg_HA/TiO2 and nHA were insignificant. It was demonstrated that biocompatibility of nAg_HA/TiO2 is almost the same as nHA.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

447-450

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.447

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Online since:

February 2007

Authors:

Jing Chao Zhang, Juan Liao, An Chun Mo, Hong Kun Wu, Yu Bao Li, Guo Yu Lv, Xiao Yu Li

Keywords:

Hydroxyapatite (HAP), Nanoparticle, Osteoblast, Silver, Titania (TiO2)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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