Carbonate Substitution and Preferred Growth Orientation of Biomimetic Apatites

Frank A. Müller; Lenka Müller; Daniel Caillard; Egle Conforto

doi:10.4028/www.scientific.net/KEM.330-332.725

Paper Titles

Biological Efficacy of Modified Structure of Polymer Surfaces for Bone Substitute
p.707

Surface Charge of Hydroxyapatite and Bone Mineral
p.713

In Situ Monitoring the Growth of HAP Crystal on the Surface of Ti/TiO₂in SBF with a Quartz Crystal Microbalance
p.717

Biomimetic Synthesis of the Nanocomposite of Phosphorylatd Chitosan and Hydroxyapatite and its Bioactivity In Vitro
p.721

Carbonate Substitution and Preferred Growth Orientation of Biomimetic Apatites
p.725

In Vitro Studies of Inflammation and Contact Activation of Titanium Oxide Film
p.729

Comparisons of the Apatite Presentation and Demineralization in Enamel and Cementum by Atomic Force Microscopy
p.733

Calcium Titanate Film-Coating on Titanium with Hydrothermal Treatments
p.737

Collagenous Molecule Immobilization on Hydroxyapatite Surface
p.741

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Carbonate Substitution and Preferred Growth Orientation of Biomimetic Apatites

Abstract:

Simulated body fluid (SBF) solutions are widely used for in vitro bioactivity tests and to coat bioinert materials with biomimetic calcium phosphates. In this study SBF solutions with varying HCO3 - content were used to precipitate hydroxy carbonated apatite (HCA) on a bioactive titanium surface. XRD as well as cross-sectional TEM analyses revealed that the biomimetically derived crystallites show a preferred growth orientation in direction of their c-axis and perpendicular to the surface of the substrate. FTIR and Raman analyses revealed that, as long as the HCO3 - concentration in the testing solutions is below 20 mmol/l, only B-type HCA precipitates. Using SBF with a HCO3 - concentration equal to human blood plasma (27 mmol/l) leads to a AB-type substitution where, in accordance with bone mineral, CO3 2- substitutes PO4 3- as well as OH-.