Paper Titles
Thick-Film CO2 Sensors Based on NASICON Synthesized by a Sol-Gel Process
p.925
Two Types of Phase Separation and Crystal Nucleation-Growth Mechanisms for Machinable Glass Ceramic
p.929
Preparation of Si-B-C System Powder Using Silicon, Boron, and Boron Carbide
p.933
Dependence of the Dielectric Properties of Pt/ZrO2/Si Capacitors Prepared by RF-Magnetron Sputtering on the Oxygen Partial Pressure and the Annealing Temperature
p.937
Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres
p.941
A Study on the Electrochemical Properties of PEO-Carbon Composite Polymer Electrolytes for Lithium/Sulfur Battery
p.945
Characteristics of Fluorine-Doped Tin Oxide Thin Films on Poly Ethylene Terephthalate (PET) Substrate
p.949
Cu/GDC Cermet Anodes by Sintering via Surface Modification with MgO Sol
p.953
Cycling Performance of LiFePO4 as the Cathode Materials for Lithium Polymer Batteries
p.957

Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres

Article Preview

Abstract:

In the paper, ampicillin-loaded alginate(ALG) microspheres covered with chitosan (CS) were firstly prepared by emulsification/internal gelation method. These microspheres were mixed with n-HA/CS composite and then were fabricated into porous scaffold carrying micropheres by gas-foaming together with phase-separation. their properties were characterized by the methods of scanning electronic microscopy (SEM), X-ray diffraction (XRD), infrared spectroscopy (IR) and inversed microscope. The drug releasing rate and entrapment efficiency were tested by spectrophotometry at 203 nm. The results show that the porous scaffold carrying microspheres has good property of slow drug releasing rate. The research will offer a new kind of degradable porous scaffold with good property of controlled drug release for bone or cartilage repairing.

You might also be interested in these eBooks
Eco-Materials Processing and Design VIII View Preview

Info:

Periodical:

Materials Science Forum (Volumes 544-545)

Pages:

941-944

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.544-545.941

Citation:

Cite this paper

Online since:

May 2007

Authors:

Pu Jiang Shi, Yu Bao Li, Li Zhang, Yi Zuo, Ming Wu, Hua Nan Wang

Keywords:

Ampicillin, Drug Release, Micro-Sphere, Porous Scaffold

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2007 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] V.R. Sinha, A.K. Singla, S. Wadhawan, R. Kumria, K. Bansal, S. Dhawan: International Journal of Pharmaceutics: 274 (2004) 1-33.

DOI: 10.1016/j.ijpharm.2003.12.026

Google Scholar

[2] Libo Yang, James S. Chu, Joseph A. Fix: International Journal of Pharmaceutics: 235 (2002) 1-15.

Google Scholar

[3] Alekha K. Dash and Greggrey C. Cudworth II: Journal of Pharmacological and Toxicological Methods: 40, 1-12(1998).

Google Scholar

[4] Anil K. Anal, Willem F. Stevens: International Journal of Pharmaceutics: 312 (2006) 166-173.

Google Scholar

[5] Zhang R, Ma PX. J Biomed Mater Res 1999; 44: 446-455.

Google Scholar

[6] P. Giunchedi, I. Genta, B. Conti, R.A. A Muzzarelli, U. Conte: Biomaterials: 19 (1998) 157-161.

DOI: 10.1016/s0142-9612(97)00181-6

Google Scholar

[7] C.C. Ribeiro, C.C. Barrias, M.A. Barbosa: Biomaterials: 25 (2004) 4363-4373. b a.

Google Scholar