Scaffold Fabrication with Biodegradable Poly(propylene fumarate) Using Microstereolithography

Jin Woo Lee; Byung  Kim; Geun Bae Lim; Dong Woo Cho

doi:10.4028/www.scientific.net/KEM.342-343.141

Paper Titles

A Developmental Study of Artificial Skin Using the Alginate Dermal Substrate
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A Mineralization Study of Various Human Dental Stem Cells
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Zonal Poisson Effect on the Chondron Deformation in Articular Cartilage under Compression
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Evaluation of Efficacy and Safety of Stem Cells as a Therapeutics, Especially Focusing on Bone Marrow Derived Stromal Cells
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Scaffold Fabrication with Biodegradable Poly(propylene fumarate) Using Microstereolithography
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Regeneration of Bone Defect Using Micro-Bioceramic PLLA Polymer Scaffolds Synthesized by Nonsolvent and Solvent Method
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Fabrication of Scaffold-Free Engineered Cartilage Using Passaged Chondrocytes in the Presence of Insuline Like Growth Factor 1 (IGF-1)
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Reinforcement Fibrin-Hyaluronic Acid Composite Gel for Tissue Engineering Cartilage Genesis
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RGD Direct Conjugation Using Co-Solvent System to Increase Cell Attachment on Poly(lactide-co-glycolide) without Change in Hydrophilic/Hydrophobic Property
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Scaffold Fabrication with Biodegradable Poly(propylene fumarate) Using Microstereolithography

Abstract:

Although tissue engineering is an area with great potential, it still has few applications due to the lack of biocompatible, biodegradable materials with suitable mechanical properties. Recently, several biodegradable materials were developed, of which poly(propylene fumarate (PPF) is one of the most notable. It degrades into fumaric acid and propylene glycol, which are both biocompatible products. Microstereolithography is a new technology that can be used to fabricate free-form 3-D microstructures by dividing a desired shape into many slices of a given horizontal thickness. This technology requires a low-viscosity resin to fabricate fine structures. However, the viscosity of PPF is too high to fabricate 3D structures using microstereolithography. Therefore, we reduced the viscosity of the resin by adding diethyl fumarate (DEF). Then, we added a photoinitiator to photo-crosslink the DEF/PPF resin, and fabricated 2.5-D scaffolds using our system. We confirmed that microstereolithography technology is effective in scaffold fabrication. The fabricated 2.5-D scaffolds were seeded with fibroblasts and the cells attached well after seeding.