Paper Titles
Vascular Smooth Muscle Cell Behaviors onto Epigallocatechin- 3-O-Gallate-Blended L-Lactide/ε-Caprolactone Copolymers
p.189
The Role of Endothelial Cells Differentiated from Bone Marrow Stem Cells in Cartilage and Bone Regeneration
p.193
High Hepatic Function Was Maintained on Electrospun Nanofibrous Scaffold
p.197
Co-Electrospinning of Microbial Polyester/Gelatin and their Interaction with Fibroblasts
p.201
Degradation Behaviors of β-TCP/PLGA Composites Prepared with Microwave Energy
p.205
Surface Modified Poly(vinyl alcohol) Nanofiber for the Artificial Corneal Stroma
p.209
Preparation and Characterization of Natural Hydroxyapatite from Animal Hard Tissues
p.213
Preparation of Macroporous Hydroxyapatite/Chitosan-Alginate Composite Scaffolds for Bone Implants
p.217
A Novel Cell Co-Culture Method Utilizing Thermo-Responsive Surface
p.221

Degradation Behaviors of β-TCP/PLGA Composites Prepared with Microwave Energy

Article Preview

Abstract:

The β-tricalcium phosphate (β-TCP)/ poly(lactide-co-glycolide) (PLGA) composites for biodegradable scaffolds in bone tissue engineering were synthesized by in situ polymerization with microwave energy. The degradation behavior of β-TCP/PLGA composite was investigated by soaking in simulated body fluid (SBF) for 4 weeks. The molecular weight of the β-TCP/PLGA composites decreased with soaking time until week 2, whereas the loss rate of molecular weight reduced after week 2. The incubation time was needed for the degradation of the β-TCP, indicating that the β-TCP should be detached from the PLGA matrix and then degraded into SBF solution. The studies of mass loss of the composites with the soaking time revealed that the degradation behavior of PLGA would be processed with the transformation from the polymer to the oligomer followed by the degradation. Morphological changes, whisker-like, due to transformation and degradation of polymer in the composites were observed after week 2. On the basis of the results, it found that the degradation behavior of β-TCP/PLGA composites was influenced by the β-TCP content in the composite and the degradation rate of the composite could be controlled by the initial molecular weight of PLGA in the composite.

You might also be interested in these eBooks
Advanced Biomaterials VII View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

205-208

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.205

Citation:

Cite this paper

Online since:

July 2007

Authors:

Hong Chae Park, Hyeong Ho Jin, Yong Taek Hyun, Won Ki Lee, Seog Young Yoon

Keywords:

Biodegradable, In Vitro, Micro-Wave, PLGA, Simulated Body Fluid (SBF), TCP

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2007 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] R.F. Service: Science Vol. 289 (2000), p.1498.

Google Scholar

[2] M. Jarcho: Clin. Orthop. (1981), p.259.

Google Scholar

[3] R. Langer: Science Vol. 249 (1990), p.1527.

Google Scholar

[4] R. Langer and J.P. Vacanti: Science Vol. 260 (1993), p.920.

Google Scholar

[5] A.A. Ignatitus, P. Augat and L.E. Claes: J. Biomater. Sci. Polymer Edn. Vol. 12 (2001), p.185.

Google Scholar

[6] H.H. Jin, S.H. Min, K.H. Hwang, I.M. Park, H.C. Park and S.Y. Yoon: Mater. Sci. Forum Vol. 510-511 (2006), p.758.

Google Scholar

[7] A. Oyane, K. Nakanishi, H.M. Kim, F. Miyaji, T. Kokubo, N. Soga and T. Nakamura: Biomaterials Vol. 20 (1999), p.79.

DOI: 10.1016/s0142-9612(98)00146-x

Google Scholar

[8] C.E. Holy, S.M. Dang, J.E. Davies and M.S. Shoichet: Biomaterials Vol. 20 (1999), p.1177.

Google Scholar

[9] S. Zhou and M.C. Hawley: Comp. Struct. Vol. 61 (2003), p.303. Fig. 5. SEM morphologies of β-TCP(30wt%)/PLGA composites after soaking test in SBF solution for (a)0, (b)1, (c)2, (d)3, and (e)4 weeks.

Google Scholar