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The Effects of Calcium Phosphate-Chitosan Block Bone Graft on the Periodontal Regeneration in One Wall Intrabony Defects in Beagle Dogs

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Abstract:

This study evaluated periodontal repair and biomaterial reaction following implantation of a newly fabricated calcium phosphate chitosan block bone and chitosan membrane on the regeneration of 1- wall intrabony defects in the beagle dogs. The surgical control group received a flap operation only, while experimental group was treated with calcium phosphate chitosan block bone and/or chitosan membrane. All dogs were uneventful healing without any complication. The subjects were sacrificed 8 weeks after the experimental surgery, and a comparative histological and histometric examination was done. Chitosan membrane group significantly enhanced bone regeneration compared to control, CaP-chitosan block bone and combination group. Chitosan membrane remnants were observed in chitosan and combination group, while CaP-chitosan bone materials were resorbed completely. These results suggest that Chitosan membrnae significantly enhanced bone and cementum formation in advanced periodontal defects.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

393-396

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.393

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Online since:

July 2007

Authors:

Sung Koo Kim, Jung Seok Lee, Gyung Joon Chae, Ui Won Jung, Yong Keun Lee, Chong Kwan Kim, Seong Ho Choi

Keywords:

Bone Graft Material, Chitosan (CS), Intrabony Defect, Periodontal Regeneration

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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