Paper Titles
Hydrogel Composed of Chitosan and Cyclodextrin and Evaluation of its Antioxidant Activity
p.705
Biomechanical Approach of Radius of Curvature on the UHMWPE Core in Artificial Intervertebral Disc Using FE Analysis
p.709
Self-Degradable Bioadhesive
p.713
Preparation and Swelling Behavior of Superporous Hydrogels: Control of Pore Structure and Surface Property
p.717
Synthesis and Biological Activities of Sulfonated Polysaccharides Having Pentofuransidic Structures
p.721
Star-Shaped Poly (Γ-Caprolactone-b-Ethylene Glycol): Synthesis, Characterization and Aggregation Behavior
p.725
Synthesis and Properties of Thermotropic Main-Chain Type Liquid Crystalline Polyurethanes Containing Biphenyl Mesogen
p.729
Enhanced Stability of Comb-Type Copolymer-Incorporated Liposomes
p.733
Preparation and Characterization of Poly(ε-Caprolactone)/Multiwalled Carbon Nanotube Composites
p.737

Synthesis and Biological Activities of Sulfonated Polysaccharides Having Pentofuransidic Structures

Article Preview

Abstract:

In order to elucidate the relationship between the structure and biological activity such as anti-HIV and blood anticoagulant activity, sulfonated polysaccharides and amino-polysaccharides having pentofuranosidic structures were synthesized. These sulfonated polysaccharides had potent anti-HIV activity in spite of low molecular weights, and which was dependent on the degree of sulfonation. For the blood anticoagulant activity, the conformation of polymer backbone and sulfamide group plays an important role on the interactions with the blood anticoagulant factor.

You might also be interested in these eBooks
Advanced Biomaterials VII View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

721-724

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.721

Citation:

Cite this paper

Online since:

July 2007

Authors:

Byung Won Kang, T. Yoshida, Jong Baek Lee, S.J. Jeon, H.D. Choi

Keywords:

Anti-HIV, Pentofuranan, Sulfonated Polysaccharide, Sulfonation

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2007 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] T. Uryu in: Artificial polysaccharides and their biological activities, in Polymer Science, edited by O Vogel/Pergamon Press Vol. 18 (1993), p.717.

Google Scholar

[2] T. Yoshida, K. Hatanaka, T. Uryu, Y. Kaneko, E. Suzuki, H. Miyano, T. Mimura, O. Yoshida and N. Yamamoto: Macromolecules Vol. 23 (1990), p.3717.

DOI: 10.1021/ma00218a001

Google Scholar

[3] I. Bjork and U. Lindahl: Molecular and Cellular Biochem. Vol. 180 (1980), p.2305.

Google Scholar

[4] P.J. Garegg and A. A Lindberg in: Carbohydrate Antigens, Am. Chem. Soc. Washinton DC, (1993).

Google Scholar

[5] K. Nagasawa and H. Yoshidome: Chem. Pharm. Bull. Vol. 17 (1969), p.1316.

Google Scholar

[6] H. Nakashima, Y. Kido, N. Kobayashi, Y. Motoki, M. Neushul and N. Yamamoto: J. Can. Res. And Cli. Oncology Vol. 113 (1987), p.413.

Google Scholar

[7] US Pharmacopoeia National Formulary, USP XXI (1985).

Google Scholar

[8] K. Hatanaka and T. Uryu, Seisan-Kenkyu, Vol. 41 (1989), p.167.

Google Scholar

[9] C. Schuerch, (1981), Advances in Carbohydrate Chemistry and Biochemistry, edited by R.S. Tipson and D. Horton, Academic Press, Inc. Vol. 39 (1981), p.157.

Google Scholar