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Study of Protein Adsorption on Biomaterial Surfaces by SPR

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Abstract:

The aim of this study was to set up a SPR sensor and to investigate protein adsorption onto biomaterial surface using it. Methods: The adsorption of human albumin (Alb), fibrinogen (Fib) and immunoglobulin G (IgG) onto polyurethane (PU) H50-50 and Au surface were measured using this SPR sensor. Results: The results of protein adsorption showed that the amount of Alb, Fib and IgG adsorbed on PU (H50-50) are smaller than Au, and on these two material surfaces, the amount sequence of adsorbed protein is: IgG> Fib > Alb. Both the Alb/Fib ratio and Alb/IgG ratio on PU (H50-50) surface are higher than Au. Conclusion: The antithrombogenicity of PU (H50-50) is better than Au.

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Advanced Biomaterials VII View Preview

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

825-828

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.825

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Online since:

July 2007

Authors:

Jian He, Xiao Ying Lü, Qing Yue Hong, Zu Hong Lu, Yan Huang, Pai Zheng Sun

Keywords:

Biocompatibility, Biosensor, Protein Adsorption, Surface Plasmon Resonance (SPR)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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