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The Effects of Antibiotics Blended Chitosan Membranes on the Calvarial Critical Size Defect in Sprague Dawley Rats

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Abstract:

The purpose of this study was to evaluate the osteogenesis of tetracycline blended chitosan membranes on the calvarial critical size defect in Sprague Dawley. An 8 mm surgical defect was created with a trephine bur in the area of the midsagittal suture. Forty rats were divided into four groups: negative control group, positive control group and two experimental groups. Three types of membranes were made and a comparative study was done. One type of non-woven membrane was made by chitosan for positive control. The other two types of non-woven membranes were made by immersing non-woven chitosan into either the tetracycline solution or the chitosan-tetracycline solution. Histologic analysis was done at 2 weeks and 8 weeks of healing periods. We concluded that that the use of tetracycline blended chitosan membrane on the calvarial defects in rats has a significant effect on the regeneration of bone tissue in itself. In addition it implicates that tetracycline blended chitosan membrane may be useful for guided tissue regeneration.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

857-860

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.857

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Online since:

July 2007

Authors:

Gyung Joon Chae, Sang Bae Lee, Ui Won Jung, Yong Keun Lee, Chong Kwan Kim, Seong Ho Choi

Keywords:

Bone Regeneration, Chitosan (CS), GTR, Tetracyclines (TCs)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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