Bioresorbable Phosphate Scaffolds for Bone Regeneration

Chiara Vitale-Brovarone; Enrica Verné; Francesco Baino; Gabriela Ciapetti; Elisa Leonardi; Nicola Baldini

doi:10.4028/www.scientific.net/KEM.361-363.241

Paper Titles

In Vitro Behavior of Fiber Bundles and Particles of Bioactive Glasses
p.225

In Vitro Assessment of New Niobium Phosphate Glasses and Glass Ceramics
p.229

Glass-Ceramic Scaffolds and Shock Waves Effect on Cells Migration
p.233

Preparation and In Vitro Characterization of Wollastonite Doped Tricalcium Phosphate Bioceramics
p.237

Bioresorbable Phosphate Scaffolds for Bone Regeneration
p.241

Rough Bioglass Films Prepared by Magnetron Sputtering
p.245

Apatite Forming Ability of Bulk Metallic Glass Surface via Hydrothermal Treatment
p.249

Growth Behavior of Rat Bone Marrow Cells on RF Magnetron Sputtered Bioglass- and Calcium Phosphate Coatings
p.253

Combined Structural Investigations of Bioactive Silicate Glasses
p.257

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Bioresorbable Phosphate Scaffolds for Bone Regeneration

Abstract:

In this work, a new bioresorbable phosphate glass (I-CEL2) was prepared in order to use it for the production of 3D-bioresorbable scaffold for bone regeneration. I-CEL2 was characterized to assess its thermal characteristics as well as its bioresorption rate in different medium such as distilled water, Tris-HCl and Simulated Body Fluid (SBF). 3D-macroporous scaffolds were prepared by mixing and pressing I-CEL2 powders and an organic phase and by treating the compact of powders at 550°C for 3 hours. The obtained scaffolds showed a very high porosity and a high resorption rate and are thus suitable candidates for a scaffold to be used as a temporary guide for bone regeneration. The initial response of human marrow stromal cells (hMSCs) has been tested on I-CEL2 surface to describe its biological potential.