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Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel

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Abstract:

Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel was loaded into the HAp microparticle in process of a spray-drying technique. The HAp-alginate beads including paclitaxel were obtained by a droplet method into barium solution as ionic cross-linkage and dehydration. Cross-sectional analyses indicated the homogeneity of HAp microparticles and barium ions inside the bead. The ratio of alginate to HAp in the beads dominated both mechanical and swelling properties. Drug-release experiment demonstrated the sustained release of paclitaxel from the beads cross-linked with barium ion for 7 days.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

535-538

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.535

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Online since:

November 2007

Authors:

Toshiyuki Ikoma, Tomohiko Yoshioka, Satoshi Nakamura, Nobutaka Hanagata, Tetsuya Abe, Masataka Sakane, Naoyuki Ochiai, M. Tanaka

Keywords:

Barium, DDS, Hydroxyapatite (HAP), Paclitaxel, Sodium Alginate, Spary Dry

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© 2008 Trans Tech Publications Ltd. All Rights Reserved

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References

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[5] S. Nsereko and M. Amiji, (2002) Biomaterials 23: 2723-2731. Fig. 2 Swelling ratio of the HAp-alginate beads cross- linked with barium ion. Fig. 3 Cumulative release of paclitaxel from the HAp-alginate beads cross-linked with barium ion.

DOI: 10.1051/e3sconf/20130141024

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[20] [15] [10] [5] [0] Swelling ratio 120100806040200 Incubation time / h A3H05-Ba A1H05-Ba A1H40-Ba.

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[25] [20] [15] [10] [5] [0] Cumulative release / µg 200 150 100.

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[50] [0] Incubation time / h A1H05-Ba A3H05-Ba A1H20-Ba.

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