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Evaluation of BAp Orientation Using Mouse Models for Osteoporosis (OPG-KO) and Osteopetrosis (op/op)

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Abstract:

Bone microstructure and its functions are maintained by the activity of bone cells such as osteoclast for bone resorption and osteoblast for bone formation. In this study, we examined the role of osteoclast on the formation of the preferential orientation of biological apatite (BAp) as a bone quality parameter using OPG-KO and op/op mouse models in which the expression of osteoclast increases for osteoporosis and decreases for osteopetrosis. The orientation degree of the BAp c-axis was analyzed by a microbeam X-ray diffraction system. We found more decrease in the preferential alignment of the BAp c-axis along the longitudinal direction of bone in the femoral bones of both OPG-KO and op/op mice at 12 weeks compared with normal control mice. We concluded that changes in the amount and activity of osteoclast affect BAp alignment, resulting in the degradation of bone microstructure in osteoporosis and osteopetrosis.

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Periodical:

Advanced Materials Research (Volumes 26-28)

Pages:

761-764

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.26-28.761

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Online since:

October 2007

Authors:

Jee Wook Lee, Takayoshi Nakano, Satoru Toyosawa, Yasuhiko Tabata, Yukichi Umakoshi

Keywords:

Biological Apatite (BAp), Bone Mineral Density, Bone Quality, Microbeam X-Ray Diffraction (XRD), Op/Op Mouse, OPG-KO Mouse, Osteoblast, Osteoclast, Osteopetrosis, Osteoporosis, Preferential Orientation, Remodeling

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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