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Structural Comparison of Ligand-Binding Domains in Estrogen-Related Receptors

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Abstract:

Estrogen-related receptors (ERRs), orphan nuclear receptors, share a significant amino acid sequence homology with estrogen receptors (ERs), yet their ligands do not respond in the same manner. In fact, some of the ligands that are known as agonists of ERs show antagonistic effect in ERRs. Accordingly, the current study investigated the structures of the ligand-binding domains using homology model building and docking studies. The results showed clear differences between the ligand-binding pockets of ERRs and ERs, thereby providing structural insights into the activities related to the ligands.

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Periodical:

Key Engineering Materials (Volumes 277-279)

Pages:

107-112

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.277-279.107

Citation:

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Online since:

January 2005

Authors:

Hye Yeon Kim, Ae Nim Pae, Yeon Joo Lee, Joon Kyu Park, Dae Sung Kim, Kwang Yeon Hwang, Myeong-Hee Yu, Eunice EunKyeong Kim

Keywords:

4-Hydroxyltamoxifen (OHT), Diethylstilbestrol (DES), Estrogen Receptor ER, Estrogen Related Receptor ERR, Homology Modeling, Ligand-Binding Domain, Orphan Nuclear Receptor

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© 2005 Trans Tech Publications Ltd. All Rights Reserved

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