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Enhanced Transdermal Delivery of Local Anesthetics by Liposome Formulation of Local Anesthetic Mixture

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Abstract:

Various concentrations of either lidocaine or tetracaine, plus combinations of lidocaine and tetracaine were formulated into liposomes to improve topical anesthesia. The topical anesthetic effects of these liposomal mixtures of local anesthetics (Lipo-MLA) were then compared with those of EMLA (Eutectic Mixture of Local Anesthetics) and single local anesthetic liposomes using a pinprick test on healthy adult volunteers. The Lipo-MLA exhibited significantly improved anesthetic effects compared to the EMLA and single local anesthetic liposomes with a faster onset time of approximately thirty minutes and duration of at least four hours. A dermal toxicity study using rats revealed that Lipo-MLA was safe at greater than 2,000 mg/kg bodyweight.

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Info:

Periodical:

Key Engineering Materials (Volumes 277-279)

Pages:

45-50

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.277-279.45

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Cite this paper

Online since:

January 2005

Authors:

Jeong Ok Lim, Su Jeong Kim, Roxane Pouliot, Woon Yi Baek

Keywords:

Drug Delivery System, Liposome, Mixture of Local Anesthetics, Topical Anesthesia, Transdermal Delivery

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© 2005 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] B. Bingham, M. Hawke and J. Halik: J Otolaryngol Vol. 20 (1991), pp.193-195.

Google Scholar

[2] J. Luotonen, K. Laitakari, H. Karjalanen and K. Jokinen: Acta Otolaryngol Vol. 462 (1992), pp.63-67.

Google Scholar

[3] A.N. Lars, B. Peter: Anesth Analg Vol. 67 (1988), pp.115-123.

Google Scholar

[4] B. Hallen, G. L. Ohlsen and A. Uppfeldt: Anesthesia Vol. 39 (1984), pp.969-972.

Google Scholar

[5] M. Foldvari, A. Gesztes and M. Mezei: J Microencapsul Vol. 7 (1990), pp.479-489.

Google Scholar

[6] D.F. MaCafferty, A.D. Woolfson, K. McClelland and V. Boston: Br J Anaesth Vol. 60 (1988), pp.64-69.

Google Scholar

[7] A.W. Chan, I.A. MacFarlane, D. Bowsher and J.A. Campbell: J Neurol Neurosurg Psychiat Vol 56 (1992), pp.56-59.

Google Scholar

[8] D. Brian, J. Edward and L. Ronal: Dermatol Surg Vol 24 (1998), pp.537-541.

Google Scholar

[9] G.R. Strichartz, V. Sanchez and G.R. Arthur: Anesth Analg Vol 71 (1990), pp.158-162.

Google Scholar

[10] M. G. Ganesan, N.D. Weiner, G. L. Flynn, K. F. H. Ho: Int J Pharm Vol. 20 (1984), pp.139-154.

Google Scholar

[11] J. Goto, H. Araki, S. Otomo, H. Aihara: Drugs Exp Clin Res Vol. 12 (1986), pp.917-921.

Google Scholar

[12] B.D. Bucalo, E.J. Mirikitani, R.L. Moy: Dermatol Surg Vol. 24 (1998), pp.537-541.

Google Scholar