Papers by Author: Carmen Gafitanu

Abstract: Rehabilitation of joints that underwent major surgery, involves reducing postoperative pain and inflammation. Many pharmaceutical product used in reducing joint pain are based on the extended-release technology and becoming increasingly important in research domain. The performance of extended-release matrix tablets is dependent on the solid dosage properties like matrix materials used, which are semi-synthetic polymer like hydroxypropyl methylcellulose (HPMC) and sodium carboxy methylcellulose (Na CMC). Depending on the properties of the polymer used, drug release from the tablets may be controlled by erosion mechanism and surface roughness. In a physiological environment, the release of drug from a solid dosage form requires a gradual erosion of solid shape with simultaneous change of surface roughness. This paper presents the influence of surface erosion of solid dosage forms on the surface roughness and the release of the analgesic and anti-inflammatory substances in a biological environment similar to the human digestive juice.

Abstract: In this paper, the mechanical properties of extended drug release systems were studied. A binder is a material that is added to a formulation in order to improve the mechanical strength of a drug release system. The drug release systems investigated were cylindrical tablets containing mixtures of various ketoprofen types and binders. Among the binders used were a series of different molecular weights of kollidon va 64, carbopol 971 pnf, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose. The samples were made in the form of cylindrical tablet of about 9 mm in diameter and containing different mixtures of drug substances and excipients in three formulations. Mechanical parameters such as hardness, tensile stress and friability were studied in order to determine how they are influenced by binder and how it influences wetting and disintegration of tables.

Abstract: Since, anti-inflamatory drugs have a high demand due to increased incidence of pain associated with different pathology; the objectives of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties for the ketoprofen-cyclodextrin complexes. The analysis of solubility for these complexes was carried out using MathCAD software. Tribological factors were evaluated by the wear resistance of cylindrical tablets containing ketoprofen-cyclodextrin complex, methocel and magnesium stearate. The tablets with ketoprofen-cyclodextrin complexes provide good solubility and wear resistance and these are ideal for preparation of extended release systems like implantable tablets or for orally administration tablets.