Papers by Author: D.H. Kim

Abstract: Ceramic ferrites can be used to cancer-treatment. Heating of certain organs or tissue up to temperature between 42oC and 45oC preferentially for cancer therapy is called hyperthermia. We synthesized ferrites with various compositions in the system Co1-xNixFe2O4 as hyperthermic thermoseed in cancer-treatment and evaluated their effects on the necrosis of cancer cells under alternating magnetic field in vivo as well as in vitro. When a CoFe2O4 was placed into 0.2 ml distilled water, the greatest temperature change in this study, Δ T=29.3oC, was observed. More than half of the carcinoma cells were dead after exposure to alternating magnetic field using CoFe2O4, while normal cells were survived more than 60%. The injection of this ferrite particles into the tumor bearing mice was able to suppress the number and volume of tumors. CoFe2O4 is expected the useful hyperthermic thermoseed in cancer-treatment because it exhibited the greatest necrosis of carcinoma cells in vitro and in vivo.

Abstract: The purpose of this study was to evaluate the cytotoxicity of alginate-encapsulting ferrite particles in vitro. Various ferrite particles such as Ba-ferrite, Sr-ferrite, Co-ferrite, Co/Ni-ferrite were prepared by sol-gel process. Ferrite particles were encapsulated via calcium alginate process with different alginate contents ranged from 10 to 100 wt%. Mouse-fibroblastic NCTC L-929 cells were cultured in RPMI-1640 medium with 10% fetal bovine serum. The alginate-encapsulating ferrites were extracted in 5 ml of distilled water under pH 6.5 at 121°C for 1 h in accordance with ISO 10993-12. In vitro cytotoxicity was evaluated by WST-1. The results of this study indicated that the alginate-encapsulting ferrite particles affected cell viability by increasing alginate contents. Especially, alginate-encapsulating process were enhanced cell viability of ferrites such as Sr-ferrite, Co/Ni-ferrite, and Ba-Ferrite when alginate content was 10 wt%.