Papers by Author: Fu Zai Cui

Abstract: An ideal injectable bone cement should be able to fill fully the fractures gap and provide good mechanical support. In the present work, the mineralized collagen and calcium sulphate dehydrate (CSD) was incorporated into α-calcium sulphate hemihydrates (α-CSH) to explore an injectable composite cement. The injectability, the setting time and the biomechanics properties were investigated. A porcine thoracolumbar burst fracture model was used to evaluate the biomechanical performance of composite cements. The porcine thoracolumbar burst fracture models in vitro were prepared. A half of models was made by the vertebroplasty of the composite cements, the other half of models was used as control. Imaging analysis showed the composite cements distributed uniformly and solidified well. Biomechanical test showed the ability of the composite cements to repair spinal burst fractures was significant.

Abstract: Every year, roughly two million patients worldwide sustain a bone grafting procedure to repair bone defects stemming from tumor, the wound, the infection, as well as other reasons [1, 2]. The bone transplantation is one of main methods to treat bone damages [3]. The gold standard is to use autologous bone or autograft [4]. However, both the need of the second surgery and morbidity at the extraction site [5-7] has been an incentive to search for alternative treatment. One of them is to form bone graft bone. Many materials have been widely chosen to form bone graft substitutes: metals, polymers, ceramics, dehydrate, and calcium phosphates [8-13]. Although these synthetic materials provide an immediate solution for many patients, their long-term performance is generally not satisfactory. This is often due to a mechanical property mismatch between the implant failure and tissue damage [14, 15]. The development of combined artificial bone with improved mechanical properties and enhanced biocompatibility calls for a biomimetic approach using natural bone as a guide.