Papers by Author: Lin Jia

Abstract: Molecular imprinted polymers (MIPs) for antitumor drug Epothilone B have been synthesized with bulk polumerization in order to specifically extract this agent in the present study. MIP was prepared by thermal polymerisation using Epothilone B as template, methacrylic acid as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linking agent. The best synthesis progenic solvent was ultimately determined when the bonding property of the polymer was studied. The selectivity of imprinted polymer on Epothilone B was also studied. The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site. Equilibrium dissociation constant was 3.37 mg/ml, the maximum apparent adsorption was 335 mg/g.

Abstract: Molecular imprinted polymers (MIPs) were synthesized in certain conditions in the experiment when tetracycline antibiotics (TCs), including Oxytetracycline, Chlortetracycline and Tetracycline were used as templates, methacrylic acid as functional monomer, and ethylene glycol dimethacrylate as cross-linker. Oxytetracycline and Chlortetracycline (1:1) were chosen as mixed-templates when the bonding property of the polymer was studied. The results showed that the mixed-templates MIPs had high selection for tetracycline, and were expected to be used as separation materials for the extraction and purification of TCs in animal food.