Papers by Author: M. Browne

Abstract: In recent years, the processing of porous ceramic materials for implant applications has motivated the development and optimization of new technologies. To this purpose, a globular protein based (i.e. ovalbumin) consolidation approach has been proposed. In the present study, a porous hydroxyapatite:b-tricalcium phosphate - biphasic ceramics (BCP), was processed by consolidation using the protein-action technique. The processed ceramic materials exhibited appropriate pore configuration in terms of size, morphology and distribution. The in vitro reactivity and dissolution behavior of the ceramics was evaluated in SBF and biocompatibility in an osteoblasts culture, respectively. Overall, the materials tested showed biocompatibility and suitable properties for osteoconduction. A rough surface pattern displayed by the ceramics seemed to have improved both; cell adhesion and proliferation processes. In conclusion, this study revealed that the porous matrices obtained, promoted suitable development of cell metabolism without cellular death.

Abstract: A modular ceramic femoral head was selected for use as the bearing on a novel carbon fibre reinforced plastic (CFRP) total hip replacement femoral stem. Mechanical testing was required to validate this novel combination of materials for load bearing implant application. The Ceramic Head-CFRP Stem Taper interface was tested under axial fatigue loads according to BS/ISO 7206-5, followed by static loading to failure. The assembly survived the fatigue loads and exceeded the required FDA post-fatigue strength by 50%. In parallel, the test was simulated in a Finite Element Analysis study, resulting in recommendations for the adhesive bonding technique used to attach the modular head to the CFRP stem to further improve its strength.