Papers by Author: Ming Dong Huang

Abstract: A novel photosensitizer, pentalysine β-carbonyl-phthalocyanine zinc [ZnPc-(Lys)₅] has tendency to form aggregate in aqueous solution. The observed in vivo Photodynamic therapy (PDT) effect of ZnPc-(Lys)₅ suggests a disaggregation mechanism. In this study, the equilibrium binding constant K_a, the numbers of binding sites n and the distance of Forster radii r between ZnPc-(Lys)₅ and human serum albumin (HSA) are measured by Spectroscopy. A molecular model of HSA-ZnPc-(Lys)₅ complex was generated according to these datum. This molecular model provides rationale that the molecular interaction between HSA and ZnPc-(Lys)₅ facilitates the dissociation of ZnPc aggregates.