Papers by Author: Tek Hyung Lee

Abstract: Poly (D,L-latic-co-glycolic acid) (PLGA) has been used as the artificial scaffold for blood vessel formation. In order to hinder smooth muscle cell (SMC) angiogenesis, new scaffold design method of loading Epigallocatechin 3-O-gallate (EGCG) on PLGA film was introduced. PLGA and EGCG were dissolved in acetone and film-shape scaffold was manufactured. Antiangiogenetic effect of EGCG released on scaffold was analyzed for SMC and human umbilical vein endothelial cell (HUVEC) and method for selective inhibition from the difference of growth of SMC and HUVEC was suggested.

Abstract: Adhesions are abnormal attachments between tissues, caused by an inflammatory stimulus or trauma. It was generally used physical barriers and various agents to prevent from adhesions formation. In this study, we made an experiment on animals with wound covering material of substance to prevent tissue adhesion. It was performed in sub-acute toxicity, and tested local effects after implantation.