Papers by Keyword: Alendronate

Abstract: Based on data from Indonesian Health Ministry in 2009, osteoporosis case reached 19,7 % of the populations in Indonesia, especially women in menopause period. The treatment was performed by consuming bisphosphonate drugs per oral which was not effective since the absorption intake of the drug was only less than 55% of the intake dosage. Because of that, the bone filler which also has a function as drug delivery system was developed. The hydroxyapatite-gelatin bone filler with the addition of alendronate was studied. To increase the characteristics of this bone filler, glutaraldehyde was introduced in the composite as a crosslinking agent. The concentration of 0.25%, 0.5%, and 0.75% were used. The bone filler was then characterized based on FTIR test, morphology test, compressive strength test, cytotoxicity test, and degradation test. The FTIR result showed that there was no significant difference between the sample with and without glutaraldehyde since the crosslinking bond of glutaraldehyde and gelatin was C=N bond which also presented in the gelatin. The morphology of the samples depicted a bigger pore size for higher glutaraldehyde concentration which also supported by lower compressive strength. All the samples were non-toxic based on the cytotoxicity test which had cell viability more than 100%. The degradation tests showed that with the presence of glutaraldehyde in the bone filler could maintain its form longer than the bone filler without glutaraldehyde. In conclusion, the presence of glutaraldehyde could increase the characteristics of the hydroxyapatite-gelatin composite with the addition of alendronate as a bone filler candidate for osteoporotic bone.

Abstract: TiO₂ nanotube arrays (TNTs) were preparation on Ti influoride containing electrolytes via anodization. Poly (diallyldimethylammonium chloride (PDDA) alternately was assembled with poly (acrylic acid) (PAA) to modified TiO₂ nanotube. the modified TiO₂ nanotube loaded with alendronate, and its release properties were investigated. The samples were characterized by scanning electronic microscope (SEM), Fourier transform infrared (FT-IR). The results show that the loading rate and loading amount of alendronate were greatly influenced by electrostatic interaction. It suggested that the PDDA/PAA multilayer films had a potential application in modifying TNTs for drug delivery.

Abstract: The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and ¹H NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate.

Abstract: TiO₂ nanotube arrays possess regular hollow structure, large specific surface area and good biocompatibility, which are good for filling with drugs. In this paper, a vertically aligned nanotube arrays of titanium oxide was fabricated on the surface of titanium substrate in fluoride-containing electrolytes by anodization. The TiO₂ nanotube arrays were loaded with alendronate via vacuum drying method and the release of alendronate from the nanotubes were detected in phosphate buffer solution(PBS). The samples were characterized by scanning electronic microscope(SEM), X-ray diffraction(XRD), Fourier transform infrared(FTIR), Thermogravimetric analysis (TG) and visible ultraviolet spectrophotometer(UV-vis). The data showed that the release of alendronate from the nanotubes includes two stages: burst release and sustained release, the result indicated that the drug loaded in the TiO₂ nanotubes has a certain amounts of sustained-release effect.