Papers by Keyword: Arsenic Trioxide

Abstract: The technology of the acidification is adopted to prepare arsenic trioxide (As2O3). With a concentration of 98% of concentrated sulfuric acid and Orpiment made into a certain ratio of the slurry suspension. Arsenic trioxide’s content is 99.94%, extraction yield can reach to 98.92%. The optimal conditions is reaction temperature at 120°Cand the reaction time in 2.5 h; the slurry ratio is less than 1/6 and particle size is less than 0.080 mm.

Abstract: Proliferation and migration of vascular smooth muscle cells(VSMCs) into the sub-intimal space play an important role in intimal thickening in atherosclerosis and in-stent restenosis. Arsenic compounds are natural substances that have been used in the treatment of patients with acute promyelocytic leukemia (APL).And Arsenic trioxide (As2O3) is known to be a potent inhibitor of cell proliferation.The aim of this study was to prepare arsenic trioxide (As2O3) -loaded PLGA nanoparticles(As2O3-PLGA-NP) and investigate its general properties, preservation of As2O3 bioactivity and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(RVSMCs) in vitro. With PLGA as carrier,As2O3 drug delivery nanoparticles were prepared by w /o /w double-emulsion evaporation technique，and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(VSMCs) in vitro was investigated.The results of the experiment show the self-prepared As2O3-PLGA-NP were approximately spherical,with the mean diameter of 90±25.03 nm, and the average drug loading was 1.72% .The As2O3-PLGA-NP has drug sustained-release character and can prolong the phase of the inhibitory effect of As2O3 against RVSMCs.The As2O3-PLGA-NP do not reduce the biological activity of As2O3.

Abstract: Studies on xCuO-(1-x)As2O3-0.7B2O3(0.01≤x≤0.05) (G1-G5: x = 0.01, 0.02, 0.03, 0.04, 0.05) glasses were done using varieties of structure sensitive techniques. The powder X-ray diffraction (XRD) studies show the formation of glasses in the composition. The IR spectral results show the presence of Cu-O bond, planar [BO3/2] and [BO3 -n](n=1, 2, 3) units and tetrahedral {BO4/2]- units. The magnetic susceptibility results show Curie-Weiss behaviour in the range 4.2-400 K. The calculated values of the exchange integral from the Weiss constant obtained form the linear fit of the Curie-Weiss law are found to be in the range 5.22-29.50 meV. From the trend of the gmatrices of gơ>g⊥>ge (ge =2.0023) obtained from electron paramagnetic resonance (EPR) lineshapes simulation we conclude that the paramagnetic site in these glasses is Cu2+(3d9) which is in a tetragonally elongated octahedron [O1/2-CuO4/2-O1/2] exhibiting Jahn-Teller distortion having D4h symmetry with orbital singlet 3dx2-y2 (2B1g) as the ground state.