Papers by Keyword: Bone Cancer

Abstract: Selenium (Se) nanoclusters were coated on three different orthopedic materials: Titanium, stainless steel and ultra high molecular weight polyethylene (UHMWPE). There different coating densities were achieved on each type of substrate. The uncoated and coated Ti and SS substrates were then used in experiments with either normal healthy osteoblasts (bone-forming cells) or cancerous osteoblasts (osteosarcoma) or a combination of both. For the first time, it was shown that the substrates coated with Se nanoclusters promoted (or at least maintained) normal osteoblast proliferation and inhibited cancerous osteoblast growth in both separate culture experiments and co-culture experiments. Thus, this study introduced to the orthopedic cancer community for the first time a coating material (Se) which may inhibit bone cancer growth and promote normal bone growth.

Abstract: Several drug delivery carriers have reported on local delivery of paclitaxel (PTX), but their effects on intraosseous cancer model are not well known. This study was conducted to clarify the therapeutic effects of our newly developed PTX-loaded HAp-alginate composite beads. Cytotoxic activity was assessed on rat’s mammary adenocarcinoma by cell proliferation assay using WST-1 reagent. Antitumor activity was assessed by 8-week-old rat female Fischer 344 rats of metastatic spine cancer. Twenty-three rats were divided into 3 groups: Group 1 (n = 7) and Group 2 (n = 8) was treated with the PTX-loaded HAp-alginate beads using strontium ions and barium ions, respectively. Group 3 (n = 8) was administered with drug-free HAp-alginate beads. We checked disease-free time and survival time among 3 groups. The HAp-alginate beads containing 2.4wt% of PTX showed significant cytotoxic activity on CRL-1666 cells. The effects were decreased with time during 72 h. The animals treated with 2.4wt% of PTX-loaded HAp-alginate beads showed 40% increase in the disease-free time and 25% increase in survival time. Our studies suggest that newly developed HAp-alginate beads can be a candidate carrier of PTX to bone.