Papers by Keyword: Bone Grafting

Abstract: The aim of this paper is to highlight the classification and indications of different bone grafting materials and barrier membrane for everyday clinical practice of contemporary work in the field of oral surgery and periodontology. Number of different growth factors are used together with graft materials. Among these are platelet rich plasma (PRP) and platelet-rich fibrin (PRF). With the simplified technique, an autologous fibrin matrix, which contains platelets and leucocyte growth factors, is acquired.

Abstract: This study evaluated the in vitro degradation of pellet, powder and plates of poly-L-DL-lactic acid (PLDLLA) after two processing methods. Part of the material was reduced to powder by cryogenic milling and part of it molded injected in plate form. The crystallinity was evaluated by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), and Gel Permeation Chromatography (GPC) before and after immersion in simulated body fluid for 30, 60, and 90 days. The glass transition temperature (T_g) of the pellets and the powder were 61.5°C, 66°C. The T_gs of the plates ranged from 59.55°C to 63.06°C. Their endothermic peaks were observed at 125°C and 120°C, which was not identified to the plates samples. The FTIR spectrum showed bands of amorphous and crystalline content. The XRD results showed a peak related to the crystalline content, and a wide reflection related to the amorphous content. The milling process increased the crystallinity and the molding injection decreased it.

Abstract: In this work, a new bioresorbable phosphate glass (I-CEL2) was prepared in order to use it for the production of 3D-bioresorbable scaffold for bone regeneration. I-CEL2 was characterized to assess its thermal characteristics as well as its bioresorption rate in different medium such as distilled water, Tris-HCl and Simulated Body Fluid (SBF). 3D-macroporous scaffolds were prepared by mixing and pressing I-CEL2 powders and an organic phase and by treating the compact of powders at 550°C for 3 hours. The obtained scaffolds showed a very high porosity and a high resorption rate and are thus suitable candidates for a scaffold to be used as a temporary guide for bone regeneration. The initial response of human marrow stromal cells (hMSCs) has been tested on I-CEL2 surface to describe its biological potential.

Abstract: Glass-ceramic scaffolds for bone grafting have been prepared using the sponge replication method and a highly bioactive silica based glass belonging to the system SiO2-P2O5- CaO-MgO-Na2O-K2O (CEL2). The parameters for the sponge impregnation were optimized in order to obtain a continuous coating of the polymeric skeleton which will lead, after the polymeric phase removal, to a resistant macroporous glass-ceramic template. A complete characterization was carried out on the obtained scaffold in order to assess its morphology and specifically its porosity and the degree of pores interconnection. A human osteoblasts cells line (MG-63) was cultured onto the scaffold and the effect of stimulation with shock waves on the cell ability of colonizing the scaffold was investigated.

Abstract: I tested the effectiveness of a particulate dentin and plaster of Paris mixture as a bone substitute. Histologic analysis indicated that all of the bone defects surrounding the implants treated with particulate dentin/plaster of Paris were filled with new bone 6 and 12 weeks after surgery. No significant differences were observed in the new bone forming activity in any species (human, bovine, pig, rabbit, and dog). No cytotoxicity was detected in cell cultures with added particulate dentin extract and no specific allergic reactions were seen in the hypersensitivity test. These results suggested that the combination of particulate dentin and plaster is suitable as an alternative bone substitute.