Papers by Keyword: Gene Carrier

Abstract: Gene vector system is the key to realize gene transduction and therapy. A proper gene vector can introduce the target gene into cells securely, efficiently, controllably and easily, and achieve purposes of gene transfection and disease treatment after its expression. ε-polylysine (ε-PL),which is rich in cationic and has high penetrability through biological membrane,can be applied in DNA carrier. In this study, we presented a novel approach for preparing ε-polylysine modified silica nanoparticles and combinating them with plasmid DNA.

Abstract: Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.