Papers by Keyword: Molecularly Imprinted

Abstract: A benefit of imprinted polymers is the possibility to prepare sorbents with selectivity pre-determined for a particular substance, or group of structural analogues. The application most close to a wider acceptance is probably that of solid phase extraction for clean-up of environmental and biological samples. The technique of molecularly imprinted polymers to solid phase extraction (MISPE) is performance and high selectively, compared with traditional sorbents. In this paper, the preparation and application of MIPs would be reviewed.

Abstract: In this paper, molecularly imprinted polymers with high selectivity for nonylphenol (NP) were synthesized by sol-gel process using 4-vinylpyridine (4-Vpy) as functional monomer, ethyleneglycol dimethacrylate as crosslinker (EGDMA), azobisisobutyronitrile (AIBN) as initiator, NP as template molecules. The performance of imprinted material was evaluated by adsorption kinetic, adsorption isotherm and adsorption selectivity. The results indicated that this material had not only binding properties but also high selectivity to the template molecule, which had good application prospects in the selective enrichment and separation of NP for pretreatment and analysis of complex environmental samples.

Abstract: Molecular imprinted polymers (MIPs) for antitumor drug Epothilone B have been synthesized with bulk polumerization in order to specifically extract this agent in the present study. MIP was prepared by thermal polymerisation using Epothilone B as template, methacrylic acid as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linking agent. The best synthesis progenic solvent was ultimately determined when the bonding property of the polymer was studied. The selectivity of imprinted polymer on Epothilone B was also studied. The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site. Equilibrium dissociation constant was 3.37 mg/ml, the maximum apparent adsorption was 335 mg/g.

Abstract: Erythromycin molecularly imprinted membranes (EM-MIMs) were prepared by wet phase inversion from imprinted polymers which were prepared by MAA as functional monomer, AN as membrane monomer and EDMA as crosslinker in the presence of erythromycin as template. The influences of the proportion of EM and MAA, cross-linking use level, different initiators and use level as well as extraction time on the imprinted sites and specific separation of EM-MIMs for EM were investigated. The results show that EM-MIMs were provided with more imprinted sites and more excellent separation properties for EM when adding MAA 0.0461mol, EM 0.724mmol, AIBN and (NH4)2S2O8 each 0.12g as initiators, and the mole ratio of EDMA and MAA at 5:1. The extraction of templates was carried out by using absolute ethyl alcohol as eluant and ultrasonic oscillating for 40min.