Papers by Keyword: Thin Film Method

Abstract: This text adopted the thin film method to prepare the vitamin E liposomes, the influence of proportion of components in vitamin E liposomes, and experiment condition on the envelopment rate were studied. The results showed that the optimum condition of the making technology of the vitamin E liposomes was:temperature42°C,m(vitamin E):m(lecithin)=1:25,m(vitamin E) :m(the cholesterol )=1:3, m(vitamin E) :m(the octadecylamine )=5:1, the phosphate buffer solution was 20 ml. In this case, the entrapment efficiency of the vitamin E liposomes was 76% .This method was accurate, and applicable for the preparation of vitamin E liposomes, and the property of it was very stable.

Abstract: A liposome is a spherical vesicle composed of phospholipids and cholesterol bilayer membrane and contains a core of aqueous solution. Liposomes are polymeric nanoparticles used for drug delivery due to their unique properties. It can carry both hydrophobic and hydrophilic molecules. In this study, we showed the benefit of using transmission electron microscope (TEM) with negative staining technique to investigate the morphology of liposomes produced by thin film method. At the same magnification of micrograph results, we could see the multilamellar vesicles of liposomes in various figures and different sizes.