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In Vivo Biological Behavior of Calcium Phosphate Cements with Different Ca/P Ratio

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Abstract:

Bioceramics with different Ca/P ratio were prepared from a mechanical mixture of NaPO3, CaCO3, Ca(OH)2 and phosphate buffer solution and implanted in rats subcutaneous tissues. The cements were characterized by Thermogravimetric analysis (TG-TDA), X-ray diffraction and 31P-NMR. The implant sites were excised after 1, 4 and 16 weeks, fixed, dehydrated, included in paraffin wax for serial cutting and examined under the light transmitted microscope. They were biocompatible and biodegradable when implanted in rat subcutaneous. None of the materials induced ectopic osteogenesis. According to the results, the studied materials seem to be able for manufacturing reabsorbable bone implants.

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Periodical:

Key Engineering Materials (Volumes 396-398)

Pages:

237-240

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.237

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Online since:

October 2008

Authors:

Sybele Saska, N.S. Nunes, Emelly Aveiro, Cristina A.C. Pavan, S.H. Santagneli, J.A.D.B. Campos, Ana Maria M. Gaspar, Sidney José Lima Ribeiro, Younes Messaddeq

Keywords:

Biocompatibility, Calcium Phosphate, In Vivo Test

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© 2009 Trans Tech Publications Ltd. All Rights Reserved

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