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Magnesium- and Zinc-Substituted Beta-Tricalcium Phosphates as Potential Bone Substitute Biomaterials
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Calcium Phosphates / Biphosphonates Combinations…Towards a Therapeutic Synergy
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Ensuring Implant Fixation and Sol-Gel Derived Ceramic Coatings
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Silica-Based Ordered Mesoporous Materials for Biomedical Applications
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A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration
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Cell Proliferation and Tissue Compatibility of Organic-Inorganic Hybrid Materials
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Rationale of Using Conventional Sol-Gel Derived SiO2 for Delivery of Biologically Active Agents
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A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration

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Abstract:

Historically the function of biomaterials has been to replace diseased, damaged and aged tissues. First generation biomaterials, including bio ceramics, were selected to be as inert as possible in order to minimize the thickness of interfacial scar tissue. Bioactive glasses provided an alternative from the 1970’s onward; second generation bioactive bonding of implants with tissues and no interfacial scar tissue. This chapter reviews the discovery that controlled release of biologically active Ca and Si ions from bioactive glasses leads to the up-regulation and activation of seven families of genes in osteoprogenitor cells that give rise to rapid bone regeneration. This finding offers the possibility of creating a new generation of gene activating bioceramics designed specially for tissue engineering and in situ regeneration of tissues.

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Periodical:

Key Engineering Materials (Volume 377)

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151-166

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https://doi.org/10.4028/www.scientific.net/KEM.377.151

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Online since:

March 2008

Authors:

Larry L. Hench, Julia M. Polak

Keywords:

Alkaline Phosphatase, Bioactive Glass, Bone, Cell Culture, Collagen, Gene Expression, Genes, Mineralization, Osteoblast, Osteocalcin, Osteoconduction, Osteogenesis, Osteoproduction, Regenerative Medicine, Tissue Engineering

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