Paper Titles
Protein Loaded Apatite Hydrogel and Protein Release from Its Cake
p.1037
Preparation of Targeting Vehicles for The Delivery of N-Bisphosphonates
p.1041
Preparation of Hydroxyapatite/Poly(ε-caprolactone) Hybrid Microspheres for Drug Release System
p.1045
Development of a Bioactive Inorganic/Organic Composite for Bone Formation Active Drug Carrier
p.1049
Preparation of Hydroxyapatite-Alginate Gels as a Carrier for Controlled Release of Paclitaxel
p.1053
Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions
p.1057
Comparison of Osteoinduction by Autologous Bone and Biphasic Calcium Phosphate Ceramic in Goats
p.1063
Quantitative Analysis of Core Binding Factor 1 (Cbfa1) and Osteocalcin in C2C12 Cells Induced by Ca/P Ceramics In Vitro
p.1067
Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate
p.1071

Preparation of Hydroxyapatite-Alginate Gels as a Carrier for Controlled Release of Paclitaxel

Article Preview

Abstract:

Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca2+-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.

You might also be interested in these eBooks
Bioceramics 19 View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

1053-1056

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.1053

Citation:

Cite this paper

Online since:

February 2007

Authors:

Tomonori Yoshioka, Toshiyuki Ikoma, Akira Monkawa, Shunji Yunoki, Tetsuya Abe, Masataka Sakane, M. Tanaka

Keywords:

Anti-Cancer Drug, Drug Delivery System, Hydroxyapatite (HAP), Paclitaxel, Paclitaxel (Taxol), Sodium Alginate, Spray-Dry

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2007 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] M. Itokazu, T. Sugiyama, T. Ohno, E. Wada and Y. Katagiri: J Biomed Mater Res Vol. 39(1998), p.536.

Google Scholar

[2] T. Matsumoto, M. Okazaki, M. Inoue, S. Yamaguchi, T. Kusunose, T. Toyonaga, Y. Hamada and J. Takahashi: Biomaterials Vol. 25(2004), p.3807.

DOI: 10.1016/j.biomaterials.2003.10.081

Google Scholar

[3] Y. Mizushima, T. Ikoma, J. Tanaka, K. Hoshi, T. Ishihara, Y. Ogawa and A. Ueno: J Controlled Release Vol. 110(2006), p.260.

DOI: 10.1016/j.jconrel.2005.09.051

Google Scholar

[4] W. Paul and C. P. Sharma: J Mater Sci Lett Vol. 16(1997), p. (2050).

Google Scholar

[5] M. Sivakumar and K. Panduranga Rao: J Biomed Mater Res Vol. 65A(2003), p.222.

Google Scholar

[6] E. Krylova, A. Ivanov, V. Orlovski, G. EL-Registan and S. Barinov: J Mater Sci: Mater Med Vol. 13(2002), p.87.

DOI: 10.1023/a:1013603106502

Google Scholar

[7] H. H. Pham, P. Luo, F. Genin and A. K. Dash: AAPS Pharm Sci Tech Vol. 3(2002), E1.

Google Scholar

[8] A. Barroug and M. J. Glimcher: J Orthop Res Vol. 20(2002).

Google Scholar