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Ce(IV) Doped TiO2 Nanoparticles and the Effect on Proliferation of BEL7402 Human Hepatoma Cells

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Abstract:

To investigate nanoparticles’ antitumor effect, a globose 30~35nm Ce(IV) doped Titanium dioxide nanoparticles (CDT) were prepared by impregnation method and characterized by X-ray diffraction (XRD) and transmission electron microscopy(TEM). Proliferation of BEL7402 human Hepatoma cells was studied in vitro by using fluorescence microscopy and Flow Cytometry. The results show that cerium elements doping enhanced thermal stability of nano-size titanium dioxide to 800°C. With UV irradiated for 8min, BEL7402 were induced a dose-dependent apoptosis by CDT, about 28.2% , 41.5% and 88.3% cells were induced apoptosis after 24h at concentration of 60, 120 and 180ug/ml respectively, relative to 3.9% of that of control group cell just only in the presence of UV.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

307-310

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.307

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Online since:

February 2007

Authors:

L. Wang, J. Mao, X.L. Zhang, M.J. Tu, B. Kan, Y.Q. Wei

Keywords:

Apoptosis, Flow Cytometry, Human Hepatoma Cell, Nanosize TiO2, Rare Earth (RE)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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