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Fabricating Hydroxyapatite–Silk Fibroin Nanocomposite by Bone Bionics

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Abstract:

In the present study, hydroxyapatite (HA) /silk fibroin (SF) nanocomposite containing 40 wt % of SF, was synthesized in an aqueous solution of CaCl2/(NH4)2HPO4 system containing SF to mimic bone structure of nano HA crystallites in organic matrix. The experimental results show that SF promotes the preferential growth of nano HA crystallites along the plane (002) which indicates the interaction between nano HA crystallites and SF. The nanocomposite with nano HA crystallites dispersed homogeneously in SF matrix possesses a compression strength of 97.6 MPa higher than that of woven bone. The methodology has a great potential for designing and engineering of biomaterials with improved biological properties. The novel nanocomposite may be used as bone substitutes and tissue engineering scaffolds.

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Bioceramics 19 View Preview

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

345-348

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.345

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Online since:

February 2007

Authors:

Biao Cui, Lie Feng Liang, Xiao Ying Lu, Jie Weng

Keywords:

Bone Bionics, Hydroxyapatite (HAP), Silk Fibroin

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] Weiner S, Wagner HD: Rev. Science. Vol. 28(1998), p.271.

Google Scholar

[2] Jeffrey DH, Elia B: Science. Vol. 294 (2001), p.1684.

Google Scholar

[3] Kaplan DL, Mello SM, Arcidiacono S, et al: Birkhauser. Boston (1998), p.103.

Google Scholar

[4] Chen JS, Lu H, Richmond J, Kaplan DL: Biomaterials. Vol. 24 (2003), p.401.

Google Scholar

[5] Megeed Z, Cappello J, Ghandehari H: Pharmaceutical Research. Vol. 19 (2002), p.954.

Google Scholar

[6] Kweon H, Ha HC, Um IC, et al: Appl. Polym. Sci. Vol. 80 (2001), p.928.

Google Scholar

[7] Altman GH, Diaz F, Jakuba C, et al: Biomaterials. Vol. 24 (2003), p.401.

Google Scholar

[8] Mori H, Tsukada M: Rev. Mol. Biotechnol. Vol. 74 (2000), p.95.

Google Scholar

[9] Takeuchi A, Ohtsuki C, Miyazaki T: Key Eng. Mater. Vol. 31 (2003), p.240.

Google Scholar

[10] Wilson D, Valluzzi R, Kaplan D: Biophysical journal. Vol. 78 (2000), p.2690.

Google Scholar

[11] Tsukada M, Goto Y, Freddi G, Shiozaki H: Appl. Polym. Sci. Vol. 45 (1992), p.1719.

Google Scholar

[12] Barralet J, Best S, Bonfield W: Biomed. Mater. Res. Vol. 5 (1997), p.79.

Google Scholar