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Calcium Phosphate Nano-Composite with Bone Morphogenetic Protein

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Abstract:

Thick coatings of bone morphogenetic protein (BMP)-calcium phosphate nano-composite were prepared by a biomimetic process, in which substrates were immersed in modified simulated body fluid containing rh-BMP2 at room temperature and pressure. In vitro analyses showed that the calcium phosphate and BMP formed stable and uniform coating of composite on surface of substrate, and that the composite derive significant improvement in tissue formation, suggesting an osteoinductive bioactive surface.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

361-364

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.361

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Online since:

February 2007

Authors:

M. Park, H. Kim, Jin Woo Lee, Kang Yong Lee, Hyun Min Kim, S.H. Moon, H.M. Lee

Keywords:

Biomimetic Process, Bone Morphogenetic Protein (BMP), Calcium Phosphate, Nanocomposite, Osteoinduction, Simulated Body Fluid (SBF)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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