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Fabrication and Characterization of Composite Microspheres Containing Carbonated Hydroxyapatite Nanoparticles

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Abstract:

Nano-sized carbonated hydroxyapatite (CHAp) particles were firstly synthesized using a nanoemulsion method. TEM analyses revealed that as-synthesized nanoparticles were calcium-deficient and spherical in shape (diameter: 16.8±2.6nm). Biocomposite microspheres comprising CHAp nanoparticles and poly(L-lactide) (PLLA) were fabricated using the single emulsion solvent evaporation technique. SEM images showed that composite microspheres were mainly 5-30 μm in size despite the change of CHAp nanoparticle content. When the CHAp nanoparticle content in composite microspheres was below 10 wt%, all nanoparticles were encapsulated within the microspheres which possessed a nanocomposite structure. DSC results showed that the crystallinity of the PLLA matrix of microspheres increased from 38 to 42% when the CHAp nanoparticle content was increased from 0 to 20 wt%. The biocomposite microspheres should be a suitable material for constructing bone tissue engineering scaffolds.

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Periodical:

Key Engineering Materials (Volumes 334-335)

Pages:

1221-1224

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.334-335.1221

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Online since:

March 2007

Authors:

Wen You Zhou, Min Wang, W.L. Cheung

Keywords:

Bone Tissue Engineering, Carbonated Hydroxyapatite, Composite Microsphere, Nanoparticle, Poly(L-Lactide)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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References

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