Zonal Poisson Effect on the Chondron Deformation in Articular Cartilage under Compression

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Abstract:

The objective of this study was to quantify the zonal difference of the in situ chondron’s Poisson effect under different magnitudes of compression. Fluorescence immunolabeling for type VI collagen was used to identify the pericellular matrix (PCM) and chondron, and a series of fluorescent confocal images were recorded and reconstructed to form quantitative three-dimensional models. The zonal variations in the mechanical response of the chondron do not appear to be due to zonal differences in PCM properties, but rather seem to result from significant inhomogeneities in relative stiffnesses of the extracellular matrix (ECM) and PCM with depth.

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Key Engineering Materials (Volumes 342-343)

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133-136

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July 2007

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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[1] Poole CA, Flint MH, Beaumont BW, J. Orthop. Res., Vol. 5 (1987), pp.509-522.

Google Scholar

[2] Buschmann MD, et al., Journal of Cell Science, Vol. 108 (1995), pp.1497-1508.

Google Scholar

[3] Fank EH, et al., Journal of Biomechanics, Vol. 33 (2000), pp.1523-1527.

Google Scholar

[4] Smith RL, et al., Journal of Rehabilitation Research and Development, Vol. 37 (2000), pp.153-161.

Google Scholar

[5] Guliak F, Erickson GR, Ping Ting-beall H, Biophysical Journal, Vol. 82 (2002), pp.720-727.

Google Scholar

[6] Knight M.M., Lee D.A., Bader D.L., Biochimica et Biophysica Acta, Vol. 1405 (1998), pp.67-77.

Google Scholar

[7] Alexopoulos LG, et al., Journal of Biomechanics, Vol. 38 (2005), pp.509-517.

Google Scholar

[8] Youn I, et al., Osteoarthritis and Cartilage, Vol. 14 (2006), pp.889-897.

Google Scholar

[9] Wu JZ, Herzog W, J. of Biomechanics, Vol. 35 (2002), pp.931-942.

Google Scholar