Paper Titles
Development of Rapid Cell Recovery System Using Temperature-Responsive Nanofiber Surfaces
p.249
In Vitro Chondrocyte Culture Using Hydrophilized PLLA Scaffold in Bioreactor System
p.253
Genotoxic Potential of Regenerated Silk Fibroin Films by Different Cross-Linking Mode
p.257
Effect of Collagen Coating on Lipid Accumulation and Differentiation on 3T3-L1 Preadipocyte Treated with Conjugated Linoleic Acid
p.261
A Novel Polycaprolactone/Hydroxyapatite Scaffold for Bone Tissue Engineering
p.265
Evaluation of Semi-Interpenetrating Polymer Networks Composed of Chitosan and Poloxamer for Artificial Skin
p.269
Effects of Mechanical Stress on the In Vitro Degradation of Porous Composite Scaffold for Bone Tissue Engineering
p.273
Bone Regeneration Materials
p.277
Muscle-Derived Stem Cell/Polymer Hybrid Mixture for the Treatment of Urinary Incontinence
p.281

A Novel Polycaprolactone/Hydroxyapatite Scaffold for Bone Tissue Engineering

Article Preview

Abstract:

In this study, novel polycaprolactone/hydroxyapatite (PCL/HA) scaffolds were prepared to increase mechanical properties and degradation of PCL/HA ones for bone tissue engineering. PCL macromers were synthesized through the reaction of PCL diol (Mn: 530, 1250, and 2000) and PCL triol (Mn: 900) with acryloyl chloride and confirmed using nuclear magnetic resonance spectrometer (NMR) and fourier transform infrared (FTIR). The PCL/HA scaffolds were prepared by cross-linking of PCL macromer in the presence of HA by UV treatment and freeze drying methods. Mechanical property and porosity as well as degradability of the PCL/HA scaffolds were also investigated. PCL/HA scaffolds showed faster degradation and higher compressive modulus than those of PCL itself due to their low crystallinity and modification of terminal groups. The pore morphology and pore sizes of the PCL/HA scaffold were checked by scanning electron microscope (SEM). Cell cytotoxicity and proliferation of MG-63 osteoblast cultured onto the PCL/HA scaffold was assessed by lactate dehydrogenase (LDH) assay and Alamar blue assay, respectively. The novel PCL/HA scaffold appears to be suitable for bone substitutes.

You might also be interested in these eBooks
Advanced Biomaterials VII View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

265-268

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.265

Citation:

Cite this paper

Online since:

July 2007

Authors:

Ho Hyun Song, Mi Kyong Yoo, Hyun Seuk Moon, Yun Jaie Choi, Hyun Chul Lee, Chong Su Cho

Keywords:

Hydroxyapatite (HAP), PCL Macromer, PCL Networks, Polycaprolactone, Tissue Engineering

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2007 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] Langer R, Vacanti JP. Science Vol. 260 (1993), p.920.

Google Scholar

[2] Hollinger JO, Brekke J, Gruskin E, Lee D. Clin Orthop Vol. 324 (1996), p.55.

Google Scholar

[3] Hutmacher DW. Biomaterials Vol. 21 (2000), p.2529.

Google Scholar

[4] Marra KG, Szen JW, Kumta PN, DiMilla PA, Weiss LE. J Biomed Mater Res Vol. 47 (1999), p.324.

Google Scholar

[5] Bezwada RS, Jamiokowski DD, Lee I, Vishvaroop A, Persivale J, Treka-Benthin S, Erneta M, Suryadevara J, Yang A, Liu S. Biomaterials Vol. 16 (1995), p.1141.

DOI: 10.1016/0142-9612(95)93577-z

Google Scholar

[6] Smith KL, Schimpf ME, Thompson KE. Adv Drug Deliv Rev Vol. 4 (1990), p.343.

Google Scholar

[7] Lemmouchi Y, Schacht E, Kageruka P, De Deken R, Diarra B, Diall O, Greets S. Biomaterials Vol. 19 (1998), p.1827.

DOI: 10.1016/s0142-9612(98)00074-x

Google Scholar

[8] Legeros RZ. Prog Crystallogr Grow Char Vol. 4 (1981), p.1.

Google Scholar

[9] de Groot K, de Putter C, Smitt P, Driessen A. Sci Ceram Vol. 11 (1981), p.433.

Google Scholar

[10] Yoon JJ, Park TK. J Biomed Mater Res Vol 55 (2001), p.401.

Google Scholar

[11] Zhang R, Ma PX. J Biomed Mater Res Vol. 45 (1999), p.285.

Google Scholar

[12] Kweon HY, Yoo MK, Park IK, Kim TH, Lee HC, Lee HS, Oh JS, Akaike T, Cho CS. Biomaterials Vol. 24 (2003), p.801.

Google Scholar

[13] Li Z, Zhang M. J Biomed Mater Res Vol. 75 (2005), p.485.

Google Scholar

[14] Altankov G, Groth T. J Mater Sci Mater Med Vol. 5 (1994), p.732.

Google Scholar