The Effects of Chitosan-Tetracycline Membrane on Periodontal Regeneration of One-Wall Intrabony Defects in Beagle Dogs

Kwang Hee Han; Gyung Joon Chae; Jung Yoo Choi; Ui Won Jung; Yong Keun Lee; Seong Ho Choi

doi:10.4028/www.scientific.net/KEM.342-343.361

Paper Titles

Chondrogenic Differentiation of Human Adipose-Derived Stem Cells in PLGA (Poly(Lactic-Co-Glycolic Acid) Scaffold
p.345

Implantation of Cultured Preadipocyte Using Chitosan/Alginate Sponge
p.349

Effect of Poly (Lactic–Co–Glycolic Acid) (75:25)/ Hydroxyapatite Composite on Chondrocyte Culture for Tissue Reconstruction
p.353

The Effects of Collagen Membrane Coated with PLGA on Bone Regeneration in Rat Calvarial Defects
p.357

The Effects of Chitosan-Tetracycline Membrane on Periodontal Regeneration of One-Wall Intrabony Defects in Beagle Dogs
p.361

Properties of Sterilized Human Skin Allografts by Gamma-Irradiation
p.365

In Vitro Evaluation of Poly ε-Caprolactone/Hydroxyapatite Composite as Scaffolds for Bone Tissue Engineering with Human Bone Marrow Stromal Cells
p.369

Evaluation of Bonding Stress for the Newly Suggested Bone Cement: Comparison with Currently Used PMMA through Animal Studies
p.373

Effect of (1→3)(1→6)-Β-Glucan Containing PLGA Scaffold on Human Dermal Fibroblast Attachment and Proliferation
p.377

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The Effects of Chitosan-Tetracycline Membrane on Periodontal Regeneration of One-Wall Intrabony Defects in Beagle Dogs

Abstract:

The aim of this study was to evaluate the regenerative effects of chitosan membranes containing tetracycline (TC) applied to surgically created one-wall intrabony defects in beagle dogs. The defects either received chitosan membrane (CH), chitosan membrane containing 0.5%, 1% TC (CH-TC0.5, CH-TC1.0) or flap operation only. The animals were sacrificed 8 weeks after the experimental surgery, and comparative histological and histometric examinations were done. The amount of junctional epithelium migration and connective tissue adhesion did not show any statistically significant differences among the groups. The amount of new cementum regeneration, and new bone regeneration were significantly greater in CH-TC1.0 group than the control (P<0.05). The results suggest that chitosan membrane combined with 1.0% TC may have beneficial effect on the regeneration of bone and cementum in intrabony periodontal defects.