Enhanced Stability of Comb-Type Copolymer-Incorporated Liposomes

Taewon Hwang; Hee Dong Han; Suk Hyun Jung; Hasoo Seong; Sun Hang Cho; Byung Cheol Shin

doi:10.4028/www.scientific.net/KEM.342-343.733

Paper Titles

Preparation and Swelling Behavior of Superporous Hydrogels: Control of Pore Structure and Surface Property
p.717

Synthesis and Biological Activities of Sulfonated Polysaccharides Having Pentofuransidic Structures
p.721

Star-Shaped Poly (Γ-Caprolactone-b-Ethylene Glycol): Synthesis, Characterization and Aggregation Behavior
p.725

Synthesis and Properties of Thermotropic Main-Chain Type Liquid Crystalline Polyurethanes Containing Biphenyl Mesogen
p.729

Enhanced Stability of Comb-Type Copolymer-Incorporated Liposomes
p.733

Preparation and Characterization of Poly(ε-Caprolactone)/Multiwalled Carbon Nanotube Composites
p.737

Preparation of Silk Fibroin/Bacterial Cellulose Composite Films and their Mechanical Properties
p.741

Evaluation of Acid-Treated Hyaluronic Acid-Based Hydrogelation
p.745

Characterization of Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel Dependent upon Poly(Ethylene Oxide)
p.749

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Enhanced Stability of Comb-Type Copolymer-Incorporated Liposomes

Abstract:

To enhance the stability of liposomes in systemic circulation, a number of liposomes modified with hydrophilic polymer such as poly(ethylene oxide) have been developed. In this study, the comb-type copolymer was prepared as a surface modifier of liposome and the polymer was anchored onto the lipid bi-layer via hydrophobic interaction between aliphatic chain of phospholipids and hydrophobic chain of the polymer. The comb-type copolymer was synthesized by radical polymerization of octadecyl acrylate (ODA), hydroxy-poly-(oxyethylene) methacrylate (HPOEM) and 2-Hydroxyethyl methacrylate (HEMA). The structure of the comb-type copolymer was confirmed by 1H-NMR analysis. The stability of the comb-type copolymer-incorporated liposomes (CCIL) in serum was investigated by measuring the amount of protein adsorbed onto liposomes. The CCIL showed a much lower amount of adsorbed protein than the other liposomes. Those results indicated that the stability of CCIL in serum was higher than those of the other liposomes. Thus, the comb-type copolymer composed of ODA-HPOEM-HEMA can be a promising surface modifier for enhancement of the stability of liposomes in systemic circulation.