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Blood Compatibility of Novel Zwitterionic PEG-Grafted Nitinol Alloy for Peripheral Arterial Stents

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Abstract:

In this study, newly synthesized zwitterionic PEG was grafted on Nitinol alloy using oxidation treatment. The surface property and blood compatibility of surface-modified Nitinols were examined. The results of surface analysis showed that the contact angle and the ratio of oxygen to carbon significantly decreased with Nitinol alloys. The total amount of fibrinogen (0.095 μg/cm2) adsorbed onto TiNi-PEG2K-N+-S- was lower than that of TiNi control (0.12 μg/cm2). The platelet adhesion decreased in the order of TiNi control > TiNi-MPEG2K > TiNi-PEG2K-N+-S. Particularly, zwitterionic PEG with PEG2K was proven better than any others. The results indicated that zwitterionic PEG surface could significantly suppress platelet adhesion and protein adsorption as compared to other samples. The present study suggested that grafted zwitterionic PEG structure may possess improved blood compatibility.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

805-808

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.805

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Online since:

July 2007

Authors:

Jae Hoon Kim, Jun Sik Son, Kwi Deok Park, Jong Man Kim, Jae Jin Kim, Kwang Duk Ahn, Dong Keun Han

Keywords:

Blood Compatibility, Nitinol Alloy, Stent, Surface Modification, Zwitterionic PEG

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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