Paper Titles
Anti-Tumorigenesis of Hollow Calcium-Phosphate Microsphere Loaded with Anti-Angiogenic Agent
p.1215
Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery
p.1219
Controlled Drug Release Using Nanoporous Alumina Capsules
p.1223
Differences of Bone Regeneration by Various Calcium Phosphate/Collagen Composites
p.1229
In Vivo Demonstration of 2 Types of Microporosity on the Kinetic of Bone Ingrowth and Biphasic Calcium Phosphate Bioceramics Resorption
p.1233
Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an In Vivo Study
p.1237
Comparative Study of Biphasic Calcium Phosphates with Different HA/TCP Ratios in Mandibular Bone Defects. Long-Term Histomorphometric Study in Minipigs
p.1241
Repairing Segmental Defect with a Composite Associating Collagen Membrane and MBCP® Combined with Total Bone Marrow Graft in Irradiated Bone Defect: an Experimental Study in Rabbit
p.1245
Quantitative Micro-Radiography of New Bones Formed around the Implant Using Parametrics X-Ray
p.1249

In Vivo Demonstration of 2 Types of Microporosity on the Kinetic of Bone Ingrowth and Biphasic Calcium Phosphate Bioceramics Resorption

Article Preview

Abstract:

Microporosity and granules size are important parameters for the development of suspension, composites and injectable bone substitutes. In this experimental study performed in a rat bone model of critical size defects, were have determined the kinetics of bioceramic resorption and bone ingrowth. Two kinds of granules (1mm in diameter) of Biphasic Calcium Phosphate BCP (60/40 HA/TCP ratio) with 20% and 40% microporosity of less of 5 microns in size, were used. Higher bone ingrowth was observed for low porosity (LP) at 3 weeks versus high porosity (HP); the contrary was measured after 6 weeks. About the kinetics of BCP resorption, significant difference between the 2 porosities was noticed, the higher for high microporosity. High porosity on time, promotes more bone ingrowth at the expense of the bioceramic than lower microporosity.

You might also be interested in these eBooks
Bioceramics 20 View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

1233-1236

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1233

Citation:

Cite this paper

Online since:

November 2007

Authors:

Oliver Malard, Helene Gautier, Guy Daculsi

Keywords:

Bioceramic, Biphasic Calcium Phosphate (BCP), Granule, Microporosity

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2008 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] Daculsi G. (1998) Biomaterials, 19: 1473-1478.

Google Scholar

[2] De Groot, K. 1988. Ann N Y Acad Sci 523: 227.

Google Scholar

[3] Le Nihouannen D, Daculsi G, Saffarzadeh A, Gauthier O, Delplace S, Pilet P, P. Layrolle. (2005) Bone. Jun; 36(6): 1086-93.

DOI: 10.1016/j.bone.2005.02.017

Google Scholar

[4] Daculsi G, Layrolle P. Osteoinductive properties of Micro Macroporous biphasic calcium phosphate bioceramics. (2004) Key Engineering Materials.; 254-256: 1005-8.

DOI: 10.4028/www.scientific.net/kem.254-256.1005

Google Scholar

[5] Malard O, Bouler Jm, Guicheux J, Heymann D, Pilet P, Coquard C, Daculsi G. (1999) J Biomed Mater Res, , 46 : 103-111.

DOI: 10.1002/(sici)1097-4636(199907)46:1<103::aid-jbm12>3.0.co;2-z

Google Scholar

[6] Daculsi G., Weiss P., Delecrin J., Grimandi G., Passuti N., Guerin F. (1994) Patent n° 94-01-414 1994235.

Google Scholar

[7] Daculsi G., Weiss P., Bouler J.M., Gauthier O., Aguado E. (1999) Bone, 25: 59-61.

Google Scholar

[8] Millot F., Grimandi G., Weiss P. Daculsi G. (1999) Cells and Mat. 9: 21-30.

Google Scholar

[9] Le Guehennec L, Layrolle P, Daculsi G. Eur Cell Mater. 2004 Sep 13; 8: 1-11.

Google Scholar

[10] Daculsi G., Khairoun I., LeGeros R., Moreau F., Pilet P., Bourges X., Weiss P., Gauthier O., (2007) Key Engineering Material, 330-332: 811-814.

DOI: 10.4028/www.scientific.net/kem.330-332.811

Google Scholar