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Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an In Vivo Study

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Abstract:

Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in the rat calvarium was followed during 60 days. A total absence of osteoconduction was observed despite a favorable chemical composition, stressing the fundamental role of particle morphology on bone regeneration. Results are discussed in relation with other literature data. Possible explanations include the disfavored accumulation of biological mediators due to the acicular shape of the particles and/or a limited accessibility for cells.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

1237-1240

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1237

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Online since:

November 2007

Authors:

Christophe Drouet, Ronan Barré, Gérard Brunel, Gérard Dechambre, Edmond Benqué, Christèle Combes, Christian Rey

Keywords:

Calcium Phosphate, Osteoconduction, Particle Morphology

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© 2008 Trans Tech Publications Ltd. All Rights Reserved

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