Preparation of Porous Synthetic Nanostructured HA Scaffold

Marie Strnadová; Jiri Protivinsky; J. Strnad; Zdenka Vejsicka

doi:10.4028/www.scientific.net/KEM.361-363.211

Paper Titles

Regulating Size, Morphology and Dispersion of Nano-Crystallites of Hydroxyapatite by pH Value and Temperature in Microemulsion System
p.195

Mg-Free Precursors for the Synthesis of Pure Phase Si-Doped α-Ca₃(PO4)₂
p.199

Effect of Mg²⁺ Addition during HA Nanoparticles Synthesis Using Ultrasonic Irradiation
p.203

Synthesis and Stability of Potassium/Carbonate Co-Substituted Hydroxyapatites
p.207

Preparation of Porous Synthetic Nanostructured HA Scaffold
p.211

Increased Osteoblast Proliferation on Hydroxyapatite Thin Coatings Produced by Right Angle Magnetron Sputtering
p.215

Crystallographic Changes of Bioceramic Composition of Cadever Bone on Heat Treatments
p.219

In Vitro Behavior of Fiber Bundles and Particles of Bioactive Glasses
p.225

In Vitro Assessment of New Niobium Phosphate Glasses and Glass Ceramics
p.229

HomeKey Engineering MaterialsKey Engineering Materials Vols. 361-363Preparation of Porous Synthetic Nanostructured HA...

Preparation of Porous Synthetic Nanostructured HA Scaffold

Abstract:

The low temperature macro and micro porous hydroxyapatite scaffold was synthesized. The synthetic nanostructured HA powder was prepared by the reaction of Ca(OH)2 and H3PO4. The ultrasound apparatus was used for the separation of the particles during the precipitation process. Hydrogen peroxide (H2O2) was used as a foaming agent. The samples were dried for 3 hours at 120°C. HA (hydroxyapatite) granules exhibited interconnected macro and micro porosity with the micro pore size in the order of 0.01 'm. The specific surface area of the precipitate reached the average value 64.8 ± 11.9 [m2.g-1]. The compressive strength of the low temperature porous HA scaffold granule was very similar to deproteinized bovine bone and other calcium phosphate ceramic materials used in bone regeneration and prepared by high temperature processes. The porosity of the scaffolds 50-75% was determined by mercury porosimetry. In-vitro cytotoxicity test proved the granules to be non toxic.